The 47th Annual Meeting of the Molecular Biology Society of Japan

Organizer: Toshifumi Inada (The University of Tokyo), Roland Beckmann (University of Munich)

Ribosome stall and collision during protein synthesis indicate a serious defect in the function of the gene product and are therefore eliminated by multiple quality control mechanisms. The understanding of the molecular mechanism and physiological function of translation quality control RQC that recognizes colliding ribosomes is progressing rapidly, as is the analysis of their physiological functions. Collision ribosomes also activate two stress responses: ZAKa-mediated Ribotoxic Stress Response (RSR) and GCN2-mediated Integrated Stress Response (ISR), leading to translational control and cell death. Moreover, the mechanisms underlying ribosome quality control and ribosome degradation have been revealed. In this symposium, we introduce the latest findings on quality control that recognize translation abnormalities and the molecular mechanisms and physiological functions of the stress responses caused by collisions and stalled ribosomes.