Session Details
[2AS-04]【E】Molecular Mechanisms of RNA and Its Regulatory Machinery in Stress Responses
Thu. Nov 28, 2024 9:00 AM - 11:15 AM JST
Thu. Nov 28, 2024 12:00 AM - 2:15 AM UTC
Thu. Nov 28, 2024 12:00 AM - 2:15 AM UTC
Room 4(Fukuoka International Congress Center, 4F 404+405+406)
Organizer: Toru Suzuki (The University of Tokyo), Takahisa Nakamura (Cincinnati Children's Hospital)
Eukaryotic cells possess mechanisms to maintain homeostasis in response to internal and external stresses, and it has become increasingly clear that RNA plays a crucial role in these processes. This symposium will highlight the latest findings on the role of RNA in stress response and homeostasis regulation. It will cover a range of topics including mRNA translation, RNA modification, and the role of extracellular RNA in intercellular communication, showcasing research from the cellular to the organismal level.
Introduction
[2AS-04-01]Ribosome stalling induces RNF10 and stress response-mediated regulation of ribosomal subunit amounts
○Toru Suzuki1, Sihan Li1, Alexander Reid Landis1, Sota Ito1, Momoko Narita1, Chisato Kikuguchi1, Miho Hoshi1, Yoshitaka Matsuo1, Toshifumi Inada1 (1. Institute of Medical Science, University of Tokyo)
[2AS-04-02]Ribosomes and the ribotoxic stress response are first-line responders to cellular stress insults
○Simon Bekker-Jensen1 (1. University of Copenhagen, Denmark)
[2AS-04-03(2P-191)]Cellular stress from tRNALeuCAA intron deletion in budding yeasts
○Sachiko Hayashi1, Ryujiro Nakamura2, Soujirou Ukeda2, Hitomi Kato2, Tohru Yoshihisa1 (1. Grad. Sch. Sci., Univ. Hyogo , 2. Facul. Sci., Univ. Hyogo)
[2AS-04-04(2P-186)]tRNA modifications orchestrate the translational response to mitochondrial stress.
○Sherif Rashad1, Shadi Al-Mesitef1, Abdulrahman Mousa1, Yuan Zhou1, Daisuke Ando1, Guangxin Sun3, Tomoko Fukuuchi2, Yuko Iwasaki1, Jingdong Xiang3, Shane R Byrne3, Jingjing Sun3, Masamitsu Maekawa1, Daisuke Saigusa2, Thomas J Begley4, Peter C Dedon3, Kuniyasu Niizuma1 (1. Tohoku University, 2. Teikyo University, 3. Massachusetts Institute of Technology, 4. University at Albany, NY, USA)
[2AS-04-05]A sequential, RNA-derived, modified adenosine pathway safeguards cellular metabolism and stress response
○Akiko Ogawa1, Satoshi Watanabe2, Allen Yi-Lun Tsai3, Shinichiro Sawa3, Kenji Inaba2, Fan-Yan Wei1 (1. IDAC, Tohoku University, 2. Kyushu University, 3. IRCAEB, Kumamoto University)
[2AS-04-06]Regulation of Inflammatory Response by RNA from Extracellular Vesicles Under Metabolic Stress
○Takahisa Nakamura1 (1. Cincinnati Children's Hospital Medical Center)
[2AS-04-07]Common pathway of microRNA-mediated EV secretion from cancer cells
○Takahiro Ochiya1 (1. Tokyo Medical University)