Session Details
[2PS-07]【E】Revisit prokaryotes translational control with cutting-edge tools
Thu. Nov 28, 2024 4:45 PM - 7:00 PM JST
Thu. Nov 28, 2024 7:45 AM - 10:00 AM UTC
Thu. Nov 28, 2024 7:45 AM - 10:00 AM UTC
Room 7(Fukuoka International Congress Center, 4F 413)
Organizer: Hirotaka Toh (RIKEN), Hiraku Takada (Toyama Prefectural University)
Translation is the core process that constitutes the synthesis of proteins, a cornerstone of life. Rather than simply manufacturing proteins uniformly, translation undergoes various evolutionary developments, showcasing a diverse array of translation control mechanisms across different biological species. Recent progress in translation control within eukaryotic organisms has advanced rapidly, employing techniques such as classical ribosome profiling and cryo-electron microscopy (Cryo-EM). How does this compare to prokaryotic organisms? In this lecture, a dynamic young researcher delving into the study of translation in prokaryotic organisms will present newly uncovered findings.
Introduction
[2PS-07-01]What we know (and what we do not know yet) about bacterial ribosome-associated quality control.
○Hiraku Takada1 (1. Toyama Prefectural University)
[2PS-07-02]Mechanism of phage sensing and abortion by toxin-antitoxin-chaperone systems
Tatsuaki Kurata1,2, Toomas Mets4, Karin Ernits1, Marcus J.O. Johansson1, Tanel Tenson4, Abel Garcia-Pino3, Gemma C. Atkinson1, ○Vasili Hauryliuk1 (1. Department of Experimental Medical Science, Lund University, 221 00 Lund, Sweden, 2. RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan, 3. Cellular and Molecular Microbiology (CM2), Faculté des Sciences, Université Libre de Bruxelles (ULB), 1050, Brussels, Belgium, 4. University of Tartu, Institute of Technology, 50411 Tartu, Estonia)
[2PS-07-03]The RNA Helicase HrpA Rescues Collided Ribosomes in E. coli
Annabelle Campbell1, Hanna Esser2, Roland Beckmann2, Rachel Green1, ○Allen R Buskirk1 (1. Johns Hopkins University School of Medicine, 2. University of Munich)
[2PS-07-04]Comprehensive search for bacterial translation arrest peptides
○Keigo Fujiwara1,2, Naoko Tsuji2, Shinobu Chiba2 (1. Natl. Inst. Genet., 2. Fac. of Life sci., Kyoto Sangyo Univ.)
[2PS-07-05(2P-197)]The mechanism of translation termination inhibition by a ribosome arrest peptide PepNL
○Yushin Ando1, Yuzuru Itoh1, Akinao Kobo2, Yuhei Chadani3, Hideki Taguchi2,4, Osamu Nureki1 (1. Grad. Sch. of Sci., Univ. of Tokyo, 2. Dept. of Life Sci. & Tech, 3. Dept. of Biol. Fac. of Sci., Okayama Univ, 4. Cell Biol. Ctr., IIR, Tokyo Tech)
[2PS-07-06]Genome-encoded ABCF factors implicated in intrinsic resistance to translation-targeted antibiotics in gut commensal and pathogenic clostridia
○Nozomu Obana1 (1. University of Tsukuba)
[2PS-07-07(2P-188)]IbpA, an Escherichia coli small Hsp, is an aggregation-sensor that regulates its own translation and heat shock response at a translational level.
○Tsukumi Miwa1, Hideki Taguchi1 (1. Tokyo Tech. IIR. CBC)
[2PS-07-08(2P-195)]Surveying tRNA modifications to unveil translation regulation underpinning bacterial pathogenesis
○Satoshi Kimura1 (1. Cornell University)
[2PS-07-09]Anatomy of footprint extension in ribosome profiling reveals a landscape of ribosome rotation in bacteria
○Hirotaka Toh1, Tomoya Fujita1,2, Takeshi Yokoyama3,4, Hideki Taguchi2,5, Takuhiro Ito6, Shintaro Iwasaki1,7 (1. RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, 2. School of Life Science and Technology, Tokyo Institute of Technology, 3. Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 4. Graduate School of Life Sciences, Tohoku University, 5. Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, 6. Laboratory for Translation Structural Biology, RIKEN Center for Biosystems Dynamics Research, 7. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo)