The 47th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Mini-Symposium : [2MS-08] Practical DNA damage response research for cancer therapy

[2MS-08]【J】Practical DNA damage response research for cancer therapy

Thu. Nov 28, 2024 3:10 PM - 4:30 PM JST
Thu. Nov 28, 2024 6:10 AM - 7:30 AM UTC
Room 8(Fukuoka International Congress Center, 4F 414)
Organizer: Junko Murai (Ehime University), Hiroyuki Sasanuma (Tokyo Metropolitan Institute of Medical Science)
Research on DNA repair and the DNA damage response has elucidated that their disruption can lead to cell death, mutagenesis, and carcinogenesis. This workshop aims to exchange the latest findings with researchers involved in the DNA damage response, discuss the practical application of their findings in cancer therapy, and address current gaps towards the goals.
3:10 PM - 3:12 PM JST(6:10 AM - 6:12 AM UTC)

Introduction

3:12 PM - 3:25 PM JST(6:12 AM - 6:25 AM UTC)

[2MS-08-01]Target the Nucleolus! Strategies to Induce Apoptosis through Ribosomal Biosynthesis Impairment

○Junko Murai1 (1. Ehime University)
Comment()
3:25 PM - 3:38 PM JST(6:25 AM - 6:38 AM UTC)

[2MS-08-02(2P-068)]Blood cell analysis of BRCA2 using targeted molecular degradation in mice

○Kosuke Yamazaki1,2, Tomohiro Iguchi2, Midori Yamaguchi3, Manami Sano2, Kazuto Takayasu2, Kosuke Yusa4, Masato Kanemaki5,6,7, Ichiro Taniuchi8, Hisao Masai1,2, Hiroyuki Sasanuma2 (1. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 2. Department of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science, 3. Laboratory for Transgenic Technology, Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, 4. Stem Cell Genetics, Institute for Frontier Life and Medical Sciences, Kyoto University, 5. Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), 6. Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), 7. Department of Biological Science, The University of Tokyo, 8. Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences)
Comment()
3:38 PM - 3:51 PM JST(6:38 AM - 6:51 AM UTC)

[2MS-08-03(2P-066)]Molecular mechanism of DNA end resection and repair pathway choice in DNA double-strand break repair

○Miki Shinohara1,2, Tomoki Tamai1, Giordano Reginato3, Ryusei Ojiri1, Kenta Sasada1, Kenichiro Matsuzaki1, Petr Cejka3, Valérie Borde4, Katsunori Sugimoto5 (1. Grad. Schl. Agri., Kindai Univ., 2. ATRI, Kindai Univ., 3. Università della Svizzera italiana (USI), 4. Institut Curie, 5. State University of New Jersey)
Comment()
3:51 PM - 4:04 PM JST(6:51 AM - 7:04 AM UTC)

[2MS-08-04(2P-174)]Interaction between CDK12 and NXF1 in DNA damage response

○Shunsuke Ebara1,2, Misaki Yoshida1, Hiroko Yamakawa1,2, Keichiro Shimokawa1, Hiroshi Tauchi2, Daisuke Morishita1 (1. Chordia Therapeutics Inc., 2. Ibaraki University)
Comment()
4:04 PM - 4:17 PM JST(7:04 AM - 7:17 AM UTC)

[2MS-08-05(2P-839)]Deciphering the mechanism of cisplatin resistance acquisition in small cell lung cancer

○Takeshi Tsuruda1, Manabu Kodama1, Keiichi Nakayama1 (1. Lab. Anticancer Strategies, Advanced Res. Inst., Inst. Sci. Tokyo)
Comment()
4:17 PM - 4:30 PM JST(7:17 AM - 7:30 AM UTC)

[2MS-08-06(2P-818)]The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors

○Akihiro Ohashi1,2 (1. National Cancer Center Japan, 2. Univ. Tokyo)
Comment()
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