The 47th Annual Meeting of the Molecular Biology Society of Japan
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Open-call Symposium : [3AS-04] Protein knockdown opens up new frontier in biology

[3AS-04]【E】Protein knockdown opens up new frontier in biology

Fri. Nov 29, 2024 9:00 AM - 11:15 AM JST
Fri. Nov 29, 2024 12:00 AM - 2:15 AM UTC
Room 4(Fukuoka International Congress Center, 4F 404+405+406)
Organizer: Masato Kanemaki (National Institute of Genetics), Yosuke Demizu (National Institute of Health Sciences)
Co-hosted by: JSPS Kakenhi Transformative Research Areas (A) "Shin-biology by protein lifetime"
The technology to remove specific proteins within cells accelerates life science research and drug discovery. In recent years, protein knockdown techniques utilizing the ubiquitin-proteasome system and autophagy have garnered attention because of their rapidity, reversibility and potential for novel drug development. Researchers developing protein knockdown technologies, such as PROTAC, IMiD, degron and AUTAC, will discuss the impact of these techniques on life science research and drug discovery.
9:00 AM - 9:05 AM JST(12:00 AM - 12:05 AM UTC)

Introduction

9:05 AM - 9:20 AM JST(12:05 AM - 12:20 AM UTC)

[3AS-04-01(3P-218)]Development of the AlissAID System: An Inducible Protein Degradation System Using Single Peptide Antibodies

○Kohei Nishimura1, Yoshitaka Ogawa1, Keisuke Obara1, Takumi Kamura1 (1. Nagoya Univ.)
Comment()
9:20 AM - 9:38 AM JST(12:20 AM - 12:38 AM UTC)

[3AS-04-02]Conditional protein degradation with a single-chain antibody-based degron system

○Moutushi Islam1,2, Takefumi Negishi2,3, Masato Kanemki1,2,4 (1. Dept. of Chromosome Sci., National Institute of Genetics, Mishima, Shizuoka, Japan, 2. The Graduate Institute for Advanced Studies, SOKENDAI, Mishima, Shizuoka, Japan, 3. Dept. of Gene Function and Phenomics, National Institute of Genetics, Mishima, Shizuoka, Japan, 4. Dept. of Biological Sci., Graduate School of Science, The University of Tokyo, Tokyo, Japan)
Comment()
9:38 AM - 9:56 AM JST(12:38 AM - 12:56 AM UTC)

[3AS-04-03]Rapid and Efficient Degrader Discovery Platform, RaPPIDSTM

○Kanae Gamo1, Naomi Kitamoto1, Shinya Yokosaka1, Shigeru Furukubo1, Ryoma Hara1, Michiko Watanabe1, Tomoaki Hayashi1, Rumiko Ono1, Kazuteru Aoki1, Toshitake Kobayashi1, Yusuke Tominari1 (1. FIMECS, Inc.)
Comment()
9:56 AM - 10:14 AM JST(12:56 AM - 1:14 AM UTC)

[3AS-04-04]Protein analysis technologies for thalidomide-based drugs using protein array and proximity biotinylation enzyme AirID

○Tatsuya Sawasaki1, Satoshi Yamanaka2 (1. Div. Cell-Free Sci. PROS, Ehime Univ., 2. Div. Proteo-Interactome. PROS, Ehime Univ.)
Comment()
10:14 AM - 10:32 AM JST(1:14 AM - 1:32 AM UTC)

[3AS-04-05]Development of Targeted Protein Degradation via the Ubiquitin-Proteasome System and Deployment of Molecular Modalities

○Hidetomo Yokoo1 (1. National Institute of Health Sciences)
Comment()
10:32 AM - 10:47 AM JST(1:32 AM - 1:47 AM UTC)

[3AS-04-06(3P-458)]A ubiquitin decoder that enhances the targeted degradation of cIAP1

○Yoshino Akizuki1, Yusuke Sato2, Fumiaki Ohtake1 (1. Hoshi Univ., 2. Tottori Univ.)
Comment()
10:47 AM - 11:05 AM JST(1:47 AM - 2:05 AM UTC)

[3AS-04-07]AUTACs: Harnessing Autophagy for Targeted Protein Degradation

○Hirokazu Arimoto1 (1. Tohoku University)
Comment()
11:05 AM - 11:15 AM JST(2:05 AM - 2:15 AM UTC)

Conclusion

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