Session Details
[3MS-08]【J】Recent advances in protein design and engineering -from molecular design to molecular evolution-
Fri. Nov 29, 2024 3:10 PM - 4:30 PM JST
Fri. Nov 29, 2024 6:10 AM - 7:30 AM UTC
Fri. Nov 29, 2024 6:10 AM - 7:30 AM UTC
Room 8(Fukuoka International Congress Center, 4F 414)
Organizer: Sota Yagi (Waseda University), Ai Niitsu (RIKEN)
Progress in protein design involves synthesizing non-natural proteins or systems composed of these proteins. It extends beyond basic science to find practical applications. However, despite designing novel sequences using computer algorithms and deep learning, only some sequences exhibit the expected properties and functions. This symposium aims to introduce research that goes beyond computer science-based design, incorporating innovative approaches like evolutionary exploration.
Introduction
[3MS-08-02]Structure and mechanism of a de novo enzyme, ferric enterobactin esterase Syn-F4
Kodai Kurihara1, Koji Umezawa2,3, Ann E. Donnelly4, Brendan Sperling4, Guanyu Liao4, Michael H. Hecht4, ○Ryoichi Arai1,2 (1. Shinshu Univ., Fac. of Textile Sci. Tech., 2. Shinshu Univ., Inst. for Biomed. Sci., 3. Shinshu Univ., Fac. of Agri., 4. Princeton Univ., Dept. of Chem.)
[3MS-08-03]Exploring how an enzyme adapts to low temperatures using ancestral sequence reconstruction
○Satoshi Akanuma1 (1. Waseda University)
[3MS-08-04]Experimental reconstruction of the evolutionary process from primitive peptide to modern diverse β-barrel folds.
○Sota Yagi1, Shunsuke Tagami2 (1. Waseda University, 2. RIKEN)