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Wed. Dec 3, 2025

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E3 ubiquitin ligase ZNRF1 regulates AIS structure and fear behavior

Abnormalities in neuronal proteostasis, which involve disruptions in protein synthesis, folding, and degradation, are key contributors to neurodegenerative and psychiatric disorders. Proteostasis is maintained by intracellular factors, with the ubiquitin chain addition and protein degradation systems playing a critical role. These systems eliminate abnormal proteins and regulate signal transduction. Dysfunction in these processes leads to protein accumulation and cell degeneration, contributing to disease development. This symposium will explore the molecular mechanisms of proteostasis abnormalities, their impact on disease onset, and potential treatment strategies.

【J】Proteostasis as a Key to Neurological disorders: A New Perspective on Ubiquitination and Protein Degradation

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[1MS-08-01]E3 ubiquitin ligase ZNRF1 regulates AIS structure and fear behavior

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