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Wed. Dec 3, 2025

Thu. Dec 4, 2025

Fri. Dec 5, 2025

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CXCR4 expression promotes memory differentiation and oxidative metabolism of CAR-T cells, enhancing AML therapy in the hypoxic bone marrow

Chimeric Antigen Receptor (CAR) T-cell therapy is a groundbreaking technology that endows cells with new functionalities, bridging the fields of regenerative medicine and gene therapy to treat a variety of diseases. While regulatory authority-approved CAR-T therapies have shown dramatic effects, several challenges remain. This symposium will build upon the successes of CAR-T therapy, focusing on advancements in cell targeting techniques and the development of novel vectors. We will share and discuss the latest insights for clinical applications of next-generation technologies, aiming to accelerate the translation of molecular biology innovations into medical practice.

【E】Beyond CAR-T: Pioneering New Horizons in Designer Cell Technology

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[2AS-10-08]CXCR4 expression promotes memory differentiation and oxidative metabolism of CAR-T cells, enhancing AML therapy in the hypoxic bone marrow

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