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Wed. Dec 3, 2025

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Diverse paternal stresses modulate the sperm epigenome and determine offspring phenotypes

The germ cell lineage, originating as primordial germ cells, is essential to produce the next generation and is maintained throughout adulthood. From embryonic stages to the neonatal period, maternal environmental factors, and in adulthood, external environments and aging, influence the metabolic state of germ cells and their supporting cells. These factors play a critical role in regulating epigenomic states and reproductive functions. However, the mechanisms underlying these interactions remain poorly understood, and research in this area is still in its early stages. This project positions these investigations within the framework of "Reprometabolism," aiming to explore the interplay between metabolic regulation, epigenomic modifications, and reproductive health.

【J】Reprometabolism: Environmental and metabolic control of the reproductive cycle

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[3MS-04-03]Diverse paternal stresses modulate the sperm epigenome and determine offspring phenotypes

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