Session Details
[2PS-08]【E】Dynamic regulation of DNA replication and genome/chromosome organization
Thu. Dec 4, 2025 2:20 PM - 4:20 PM JST
Thu. Dec 4, 2025 5:20 AM - 7:20 AM UTC
Thu. Dec 4, 2025 5:20 AM - 7:20 AM UTC
Room 8(Pacifico Yokohama Conference Center 3F, 315)
Organizer: Ichiro Hiratani (RIKEN), Masato Kanemaki (National Institute of Genetics)
Just as the double-helix structure of DNA immediately predicted the semi-conservative nature of DNA replication, the relationship between DNA replication and genome/chromatin structure is inseparable. Recent studies have revealed that this relationship extends to chromatin domains on the megabase scale and is associated with diverse chromosomal functions. In this workshop, we will invite prominent speakers tackling this topic from various perspectives and scales to provide an overview of the current state of research.
Introduction
[2PS-08-01]Symmetric Histone Recycling and Replisome Coordination during Eukaryotic DNA Replication
○Tsuyoshi Terakawa1 (1. Kyoto University)
[2PS-08-02]Mechanism of Sororin loading during DNA replication
○Tomoko Nishiyama1 (1. Kyoto University)
[2PS-08-03(2P-054)]Analysis of the molecular mechanism of MCM2-7 phosphorylation by DDK using an in vitro reconstitution system
○Yugo Zaizen1, Marin Fukatsu1, Miyako Shiraishi1, Yoko Katsuki1, Yasunori Noguchi1, Masatoshi Fujita1 (1. Kyushu University)
[2PS-08-04]TRESLIN-MTBP is a limiting factor that defines initiation zones and replication timing, regulated by the opposing activities of DDK and RIF1-PP1
○XIAOXUAN ZHU1, Atabek Bektash1,2, Yuki Hatoyama1, Sachiko Sakamoto1, Shin-Ya Isobe3, Chikashi Obuse3, Atsushi Toyoda4, Yasukazu Daigaku5, Chun-Long Chen6, Masato T. Kanemaki1,2,7 (1. National Institute of Genetics, Department of Chromosome Science, Mishima, Shizuoka, Japan, 2. SOKENDAI, Graduate Institute for Advanced Studies, Mishima, Shizuoka, Japan, 3. Osaka University, Department of Biological Sciences, Osaka, Japan, 4. National Institute of Genetics, Research Organization of Information and Systems (ROIS), Mishima, Shizuoka, Japan, 5. Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan, 6. Institut Curie, Université PSL, Sorbonne Université, Dynamics of Genetic Information, Paris, France, 7. The University of Tokyo, Department of Biological Science, Tokyo, Japan)
[2PS-08-05]Embryo-specific regulation of DNA replication and 3D genome organization in mice
○Saori Takahashi1, Hirohisa Kyogoku1,2, Takuya Hayakawa3, Hisashi Miura1, Asami Oji1, Yoshiko Kondo1, Shin-ichiro Takebayashi3, Tomoya S. Kitajima1, Ichiro Hiratani1 (1. RIKEN, BDR, 2. Graduate School of Agricultural Science, Kobe University, 3. Graduate School of Bioresources, Mie University)
[2PS-08-06]Replication-dependent histone (Repli-Histo) labeling dissects the physical properties of euchromatin/heterochromatin in living human cells
○Katsuhiko Minami1,2, Kako Nakazato1,2, Satoru Ide1,2, Kazunari Kaizu3,4, Koichi Higashi1,2, Sachiko Tamura1, Atsushi Toyoda1, Koichi Takahashi3, Ken Kurokawa1,2, Kazuhiro Maeshima1,2 (1. National Institute of Genetics, 2. SOKENDAI, 3. RIKEN Center for Biosystems Dynamics, 4. ExCELLS, National Institutes of Natural Sciences)
[2PS-08-07(2P-058)]Genome-wide mapping reveals intrinsic roles of error-prone polymerases in human DNA replication.
○Lewis John Bainbridge1, Yuji Masuda2,3, Kanae Kaneko1, Tamiko Minamisawa1, Mami Takahashi1, Chikahide Masutani2,3, Yasukazu Daigaku1 (1. Japanese Foundation for Cancer Research, 2. Nagoya University, 3. Nagoya University Graduate School of Medicine)