Session Details
[3MS-15]【J】Pathophysiology driven by single-cell analysis: harmonizing computational and experimental approaches
Fri. Dec 5, 2025 11:15 AM - 12:35 PM JST
Fri. Dec 5, 2025 2:15 AM - 3:35 AM UTC
Fri. Dec 5, 2025 2:15 AM - 3:35 AM UTC
Room 15(Pacifico Yokohama Conference Center 5F, 501)
Organizer: Masaya Yamazaki (Japanese Foundation for Cancer Research), Nariaki Asada (University Medical Center Hamburg-Eppendorf)
Recent advancements in single-cell technologies have illuminated the heterogeneity of cells during development, homeostasis, and disease progression. While creating cellular atlases, such as Human Cell Atlas, is relatively straightforward, functional characterization of specific cellular subpopulations remains a significant challenge due to the complexity of experimental setups. This symposium will feature emerging young researchers who integrate single-cell analysis with functional analyses to advance their studies. Particularly, practical tips and common pitfalls in computational and experimental approaches will be discussed.
Introduction
[3MS-15-01]Elucidation of the mechanisms underlying cellular cell diversity and cancer progression originating from tumor-initiating cells
○Masaya Yamazaki1, Takatsugu Ishimoto1 (1. The Foundation For Cancer Research., Japan)
[3MS-15-02]Dissecting lymphocyte heterogeneity in autoimmune diseases using single-cell RNA sequencing
○Nariaki Asada1 (1. University Medical Center Hamburg-Eppendorf)
[3MS-15-03]Zooming into Hair Follicle Development with Multi-Omics and Live Imaging
○Ritsuko MORITA Morita1 (1. The University of Osaka)
[3MS-15-04]Optimizing high-dimensional immunophenotyping with spectral flow cytometry to design T and B cell panel in human PBMCs
○Shu Horiuchi1, Evan Rossignol1, Nedzad Music1, Giuseppe Palladino1, Arik Elfassy1 (1. CSL Seqirus)
[3MS-15-05(3P-736)]Elucidating the Molecular Mechanisms of Epilepsy through Single-Cell Spatial Transcriptomic Analysis
○Satoshi Miyashita1, Nao Tabe1, Keiya Iijima2, Kaoru Yagita3, Kazumi Shimaoka1, Shuyu He1, Minami Mizuno1, Ayane Hosaka1, Masaki Takao3, Tomoki Nishioka4, Tomoo Owa1, Masaki Iwasaki2, Mikio Hoshino1 (1. Department of Biochemistry and Cellular biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 2. Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, 3. Department of Clinical Laboratory and Internal Medicine, , National Center Hospital, National Center of Neurology and Psychiatry, 4. Division of Cell Biology, International Center for Brain Science, Fujita Health University)
[3MS-15-06(3P-880)]Identification of pancreatic cancer stem cells by single cell analysis and development of therapeutic methods
○Osamu Sugahara1, Tsunaki Higa1, Keiichi I. Nakayama1 (1. Institute of Science Tokyo)
[3MS-15-07(3P-935)]Single-cell and spatial transcriptomics to identify Mitochondrial Disease progression and treatment targets.
○Tasneem Qaqorh1, Yusuke Takahashi1, Kohei Sameshima1, Kentaro Otani1, Issei Yazawa1, Yuya Nishida1, Kohei Otani1, Yoshitaka Fujihara1, Mizuki Honda2, Shinya Oki2, Yasuyuki Ohkawa3, David R. Thorburn4, Ann E. Frazier4, Atsuhito Takeda5, Yoshihiko Ikeda1, Heima Sakaguchi1, Takuya Watanabe1, Norihide Fukushima1, Yasumasa Tsukamoto1, Naomasa Makita1, Osamu Yamaguchi1, Kei Murayama6, Akira Ohtake7, Yasushi Okazaki8, Takanari Kimura9, Hisakazu Kato9, Hijiri Inoue9, Ken Matsuoka9, Seiji Takashima9, Yasunori Shintani1 (1. National Cerebral and Cardiovascular Center, 2. Kyoto University, 3. Kyushu University, 4. Murdoch Children’s Research Institute, Royal Children’s Hospital, and University of Melbourne, 5. Hokkaido University, 6. Chiba Children’s Hospital, 7. Saitama Medical University, 8. Juntendo University, 9. Osaka University)
[3MS-15-08(3P-879)]Elucidation of IL-7R–Mediated Central Nervous System Infiltration in Acute Lymphoblastic Leukemia and the Development of a Targeted Therapeutic Strategy
○Motochika Hamada1,2, Hiroki Takashima1, Masahiro Yasunaga1,2 (1. Center for Advanced Medical Development, National Cancer Center, 2. Department of Advanced Life Sciences, Graduate School of Frontier Sciences, The University of Tokyo)
[3MS-15-09(3P-365)]The Malignant Evolution Illuminated Based on Karyotypic and Transcriptomic Tracing
○Shengyue Lei1,2, Minji Jo1, Utako Kato1, Toru Hirota1,2 (1. Cancer Institute, Japanese Foundation for Cancer Research, 2. Dept. JFCR., Institute of Science Tokyo)