Presentation Information
[2WD06a1-04]A novel structure of oligonucleotides administered intracerebroventricularly improves efficacy and alleviates acute toxicity in mice
*Su Su Lei Mon1, Kotaro Yoshioka1, Chunyan Jia1, Taiki Kuineda1, Yutaro Asami1, Kie Yoshida-Tanaka1, Wenying Piao1, Hiroya Kuwahara1, Kazutaka Nishina1, Tetsuya Nagata1, Takanori Yokota1 (1. 1Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences and Center for Brain Integration Research, Tokyo Medical and Dental University (TMDU), Tokyo, Japan)
Keywords:
Central nervous system,Antisense oligonucleotides,Intracerebroventricular injection,Overhanging duplex oligonucleotides
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