[2P] 70 Neurodegenerative Disorders | NEURO2024

Session Details

PosterG. Basic and Clinical Science of Neurological Disorders

[2P]70 Neurodegenerative Disorders

Thu. Jul 25, 2024 12:50 PM - 1:50 PM JST
Thu. Jul 25, 2024 3:50 AM - 4:50 AM UTC

Poster Room Marine Messe Fukuoka Hall B

[2P-323]Investigating the Protective Mechanisms of Protein Disulfide Isomerase (PDI) in Amyotrophic Lateral Sclerosis (ALS)

*Zeinab Takalloo Bighash¹, Sonam Parakh¹, Julie D Atkin^1,2 (1. Macquarie Medical School, Macquarie University Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia. , 2. La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, Australia.)

[2P-325]Comparative analysis of ER-Golgi SNARE protein expression and βAPP processing in neuronal cells under organelle stress

*Kei Suga^1,2, Sachiko Yamamoto-Hijikata¹, Yasuo Terao², Makoto Ushimaru¹ (1. Dept. Chem. Kyorin Univ., Faculty of Med., Tokyo, JapanDept. Chem. Kyorin Univ., Faculty of Med., Tokyo, Japan, 2. Dept. Med. Physiol., Kyorin Univ., Faculty of Med., Tokyo, Japan)

[2P-327]Imaging analysis of impaired interhemispheric communication caused by demyelination in cuprizone-induced multiple sclerosis mouse model using voltage-sensitive dye

*Kyoka Tsukuda^1,2, Michiko Miwa³, Makiko Taketoshi², Yoko Tominaga², Kentaro Nakashima^1,2,3, Takashi Tominaga^1,2,3 (1. Grad Sch of Pharm Sci, Tokushima Bunri Univ, Japan, 2. Inst of Neurosci, Tokushima Bunri Univ, Japan, 3. Kagawa Sch of Pharm Sci, Tokushima Bunri Univ, Japan)

[2P-329]Neuroinflammation potentiates α-synuclein pathology in a mouse model of Parkinson's disease

*Hideki Hayakawa¹, Kousuke Baba², Hiroshi Sakiyama¹, Chi-Jing Choong¹, Yasuyoshi Kimura¹, Kensuke Ikenaka¹, Cesar Aguirre¹, Tatsusada Okuno¹, Seiichi Nagano^1,2, Yoshitaka Nagai³, Hideki Mochizuki ¹ (1. Department of Neurology, Osaka University Graduate School of Medicine , 2. Department of Neurotherapeutics, Osaka University Graduate School of Medicine, 3. Department of Neurology, Faculty of Medicine, Kindai University)

[2P-331]Clinical survey study on chorea-acanthocytosis

*Kazutaka Sainohira¹, Shinichiro Tagawa¹, Yoshiaki Nishizawa¹, Hanae Hiwatashi¹, Izumi Yokoyama¹, Kensuke Imamura¹, Hitoshi Sakimoto¹, Yuka Urata¹, Kaoru Arai¹, Natsuki Sasaki¹, Masayuki Nakamura (1. DEPARTMENT OF PSYCHIATRY KAGOSHIMA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES)

[2P-333]Non-invasive photo-oxygenation reduces intracellular tau amyloid in the brain of tau model mice

*Yukiko Hori¹, Takanobu Suzuki¹, Taka Sawazaki^2,3, Makoto Higuchi⁴, Youhei Sohma^2,3, Motomu Kanai², Taisuke Tomita¹ (1. Lab. of Neuropathology and Neuroscience, Grad. Sch. Pharm. Sci., Univ. of Tokyo, Japan, 2. Lab. of Synthetic Organic Chemistry, Grad. Sch. Pharm. Sci., Univ. of Tokyo, Japan, 3. Dept. of Medicinal Chemistry, Sch. Pharm. Sci., Wakayama Medical Univ., Japan, 4. Dept. of Functional Brain Imaging, QST, Japan)

[2P-335]RNA-seq analysis of neurodegeneration caused by hypofunction of thioredoxin

*Iori Ohmori¹, Mamoru Ouchida², Saeko Ishida³, Tomoji Mashimo³ (1. Okayama University, 2. Okayama University, 3. University of Tokyo)

[2P-337]Hippocampal acetylcholine receptor activation-dependent long-term depression in streptozotocin-induced diabetic rats

*Sachie Hamada^1,2, Hayuma Otsuka², Hitoshi Ishibashi¹, Jun-Ichiro Oka² (1. Sch of Allied Health Sci, Kitasato Univ, Kanagawa, Japan, 2. Faculty of Pharm Sci, Tokyo Univ of Sci, Chiba, Japan)

[2P-339]Cell-type specific accumulation of alpha-synuclein aggregates in the brains of mice which received injections of alpha-synuclein preformed fibrils into the striatum

*Hiroshi Kameda^1,2, Kakeru Ogasawara², Shinichiro Okamoto^1,2,3, Masato Koike^1,2 (1. Dept Med, Juntendo Univ, Tokyo, Japan, 2. Grad Sch Med, Juntendo Univ, Tokyo, Japan, 3. Adv Res Inst Health Sci, Juntendo Univ, Tokyo, Japan)

[2P-341]Spatial transcriptomics reveals temporal expression changes in the vicinity of α-synuclein that prior to motor dysfunction in a mouse model of multiple system atrophy

*Yoshino Yonezu^1,2, Shogo Tanabe¹, Hidemi Misawa², Rieko Muramatsu¹ (1. Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 2. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Keio University)

[2P-345]Protein disulfide isomerase promotes liquid-liquid phase separation of TDP-43

*Akira Ishiguro¹, Keiko Nishijima², Yuta Murakami³, Hiroshi kimura³, Shinji Hadano^2,4, Asako Otomo^2,4 (1. Hosei University, 2. Molecular Neuropathobiology Laboratory, Department of Molecular Life Sciences, Tokai University School of Medicine, 3. Graduate School of Engineering, Tokai University, 4. Micro/Nano Technology Center, Tokai University)

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