Session Details
[HT-06]Hot Topics 06 Emerging advancements in pathophysiology and treatment of late-onset epilepsy
Fri. May 23, 2025 3:00 PM - 5:00 PM JST
Fri. May 23, 2025 6:00 AM - 8:00 AM UTC
Fri. May 23, 2025 6:00 AM - 8:00 AM UTC
第07会場(大阪国際会議場12F 特別会議場)
Chairs: Hiroshi Shigeto（Division of Medical Technology, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Japan）, Riki Matsumoto（Department of Neurology, Kyoto University Graduate School of Medicine, Japan）
In the super-ageing societies like Japan, incidence of elderly-onset epilepsy is increasing. However, this treatable condition yet has received comparatively little attention in this age group. Underlying etiology ranges from stroke, head trauma to proteinopathies such as Alzheimer disease, while etiology is not exactly known in approximately one-third. We introduce the recent advancements in the pathophysiology and treatment in older people with epilepsy, focusing on 1) the risk factors and impact of epilepsy in patients with stroke or small vessel diseases, 2) the association between epilepsy and proteinopathy for disease progression and potential treatments with anti-seizure medicine, 3) diagnosis and treatment of the status-epilepticus in the elderly.
[HT-06-1]What do we know about post-stroke epilepsy in Year 2025?
Tomotaka Tanaka (Department of Neurology, National Cerebral and Cardiovascular Center, Japan)
2022－ Senior Consultant (Head), National Cerebral and Cardiovascular Center, Japan
2020－2022 Clinical staff of Neurology, National Cerebral and Cardiovascular Center, Japan
2018－2020 Clinical research fellow, University of Singapore, Singapore
2013－2018 Clinical staff of Neurology, National Cerebral and Cardiovascular Center, Japan
2011－2013 Senior resident of Stroke and Cerebrovascular Diseases, National Cerebral and
Cardiovascular Center, Japan
2008－2011 Junior resident of Stroke and Cerebrovascular Diseases, National Cerebral and
Cardiovascular Center, Japan
2005－2008 Medical intern, National Hospital Organization Okayama Medical Center, Japan
1999－2005 Medical Student, Shimane University, Japan
2020－2022 Clinical staff of Neurology, National Cerebral and Cardiovascular Center, Japan
2018－2020 Clinical research fellow, University of Singapore, Singapore
2013－2018 Clinical staff of Neurology, National Cerebral and Cardiovascular Center, Japan
2011－2013 Senior resident of Stroke and Cerebrovascular Diseases, National Cerebral and
Cardiovascular Center, Japan
2008－2011 Junior resident of Stroke and Cerebrovascular Diseases, National Cerebral and
Cardiovascular Center, Japan
2005－2008 Medical intern, National Hospital Organization Okayama Medical Center, Japan
1999－2005 Medical Student, Shimane University, Japan
[HT-06-2]Silent spikes in the preclinical/MCI phase of dementia: what's it all about?
Riki Matsumoto1, Hisatomo Kowa2 (1.Department of Neurology, Kyoto University Graduate School of Medicine, Japan, 2.Department of Rehabilitation Science, Kobe University Graduate School of Medicine, Japan)
Prof. Riki Matsumoto graduated Kyoto University Graduate School of Medicine in 1994. After residency in Kyoto University and affiliated hospitals, he had subspecialty training in Kyoto University Graduate School and Cleveland Clinic, and obtained PhD thesis in 2003. He then worked in the Department of Neurology, Kyoto University Hospital as young faculty, lecturer and associate professor. He was appointed as the Professor of the Division of Neurology at Kobe University Graduate School of Medicine in Dec, 2018. Since Oct, 2024, he currently serves as the Professor and Chair of the Department of Neurology, Kyoto University Graduate School of Medicine. His research interests include the brain connectomics of normal physiology, pathophysiology and plasticity by integrating neurophysiological techniques including CCEP, the development of physiologic biomarkers of epileptogenicity, the interaction between dementia and epilepsy, and R&D of wearable EEG devices.
[HT-06-3]Network Hyperexcitability in Alzheimers Disease: An Early Intervention Opportunity
Keith Vossel (Professor and Director of the Alzheimer's Disease Research Center, UCLA, USA)
Dr. Keith Vossel is the Michael M. Minchin, Jr., President, J.D. French Alzheimer’s Foundation Endowed Chair, Director of the Alzheimer’s Disease Research Center, and Professor of Neurology at UCLA. He leads a multidisciplinary center dedicated to advancing equity in dementia recognition and care while developing innovative therapies through outreach, neuroimaging, neurophysiology, genetics, clinical trials, and clinical programs.
Dr. Vossel received a master’s degree in biomedical engineering and medical degree with highest honors from the University of Tennessee. He completed his neurology residency at Harvard Massachusetts General Hospital, serving as chief resident, followed by a fellowship in behavioral neurology and dementia research at UCSF and the Gladstone Institutes.
Dr. Vossel investigates Alzheimer's disease and related dementias, focusing on brain rhythm abnormalities and translational therapies. His groundbreaking research on subclinical epileptic activity in Alzheimer’s disease has inspired global investigations into this phenomenon across diverse populations.
Dr. Vossel has been honored by many awards including the John Douglas French Alzheimer's Distinguished Research Scholar Award, the Alzheimer’s Association’s Part the Cloud Translational Research Award, the Bernese Epilepsy Award from the University of Bern, and the Outstanding Health Care Innovator Award from the Los Angeles Business Journal.
Dr. Vossel received a master’s degree in biomedical engineering and medical degree with highest honors from the University of Tennessee. He completed his neurology residency at Harvard Massachusetts General Hospital, serving as chief resident, followed by a fellowship in behavioral neurology and dementia research at UCSF and the Gladstone Institutes.
Dr. Vossel investigates Alzheimer's disease and related dementias, focusing on brain rhythm abnormalities and translational therapies. His groundbreaking research on subclinical epileptic activity in Alzheimer’s disease has inspired global investigations into this phenomenon across diverse populations.
Dr. Vossel has been honored by many awards including the John Douglas French Alzheimer's Distinguished Research Scholar Award, the Alzheimer’s Association’s Part the Cloud Translational Research Award, the Bernese Epilepsy Award from the University of Bern, and the Outstanding Health Care Innovator Award from the Los Angeles Business Journal.
[HT-06-4]State-of-the-art diagnosis and treatment of status epilepticus in the elderly
Hajime Yoshimura (Department of Neurology, Kobe City Medical Center General Hospital, Japan)
EDUCATION:
2017 Ph.D. (Medicine) Kyoto University, Kyoto, Japan
2003 M.D. Faculty of Medicine, Kyoto University, Kyoto, Japan
WORK EXPERIENCE:
2017-present Chief Physician, Department of Neurology, Kobe City Medical Center General Hospital, Kobe, Japan
(2015 Jul-Sep EEG/Epilepsy Fellow, Department of Neurology, Kyoto University of Graduate School of Medicine, Kyoto, Japan)
2011-2017 Assistant Chief Physician, Department of Neurology, Kobe City Medical Center General Hospital, Kobe, Japan
2009-2011 Researcher, Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
2008-2009 Physician, Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
2005-2008 Senior Resident (Neurology), Department of Neurology, Kobe City General Hospital, Kobe, Japan
2003-2005 Resident (Internal Medicine), Kobe City General Hospital, Kobe, Japan
2017 Ph.D. (Medicine) Kyoto University, Kyoto, Japan
2003 M.D. Faculty of Medicine, Kyoto University, Kyoto, Japan
WORK EXPERIENCE:
2017-present Chief Physician, Department of Neurology, Kobe City Medical Center General Hospital, Kobe, Japan
(2015 Jul-Sep EEG/Epilepsy Fellow, Department of Neurology, Kyoto University of Graduate School of Medicine, Kyoto, Japan)
2011-2017 Assistant Chief Physician, Department of Neurology, Kobe City Medical Center General Hospital, Kobe, Japan
2009-2011 Researcher, Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
2008-2009 Physician, Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
2005-2008 Senior Resident (Neurology), Department of Neurology, Kobe City General Hospital, Kobe, Japan
2003-2005 Resident (Internal Medicine), Kobe City General Hospital, Kobe, Japan