Session Details
[S-07]Symposium 07 New Frontiers in Hereditary Cerebral Small Vessel Disease with Hemorrhage
Wed. May 21, 2025 1:20 PM - 3:20 PM JST
Wed. May 21, 2025 4:20 AM - 6:20 AM UTC
Wed. May 21, 2025 4:20 AM - 6:20 AM UTC
第07会場(大阪国際会議場12F 特別会議場)
Chairs: Osamu Onodera（BRI, Niigata University, Japan）, Masafumi Ihara（Department of Neurology, National Cerebral and Cardiovascular Center, Japan）
Recent discoveries of specific genetic mutations in Notch3, Col4A1, and ABCC6 have significantly advanced our understanding of hemorrhagic cerebral small vessel disease (CSVD). This symposium aims to explore these findings and their implications for diagnosis, treatment, and prevention. Leading researchers and clinicians will present cutting-edge research on these genetic factors, discussing their roles in vessel fragility and hemorrhage. We'll examine Notch3 mutations beyond CADASIL, Col4A1's impact on basement membrane integrity, and ABCC6's involvement in CSVD and potential systemic manifestations.
The symposium will focus on presenting the latest research findings, exploring mechanisms linking mutations to hemorrhagic CSVD, discussing implications for personalized medicine and targeted therapies, and identifying key areas for future research and collaboration. By fostering interdisciplinary dialogue, we aim to accelerate progress in understanding and managing hemorrhagic CSVD, ultimately improving patient care and outcomes in this critical area of neurovascular health.
The symposium will focus on presenting the latest research findings, exploring mechanisms linking mutations to hemorrhagic CSVD, discussing implications for personalized medicine and targeted therapies, and identifying key areas for future research and collaboration. By fostering interdisciplinary dialogue, we aim to accelerate progress in understanding and managing hemorrhagic CSVD, ultimately improving patient care and outcomes in this critical area of neurovascular health.
[S-07-1]Spatial Distribution of Cerebral Microbleeds Reveals Heterogeneous Pathogenesis in CADASIL
Sung-Chun Tang (Department of Neurology, National Taiwan University Hospital, Taiwan)
Dr. Sung-Chun Tang is currently a Professor in the Department of Neurology and the Director of the
Stroke Center at National Taiwan University Hospital. Dr. Tang received his MD from the College of
Medicine and his PhD from the Graduate Institute of Clinical Medicine at National Taiwan University.
After completing his neurology residency training at NTUH, he participated in a two-year exchange
program in the laboratory of Professor Mark P. Mattson at the National Institute on Aging, NIH, during
2005-2006. In addition to his basic stroke research, Dr. Tang has a strong interest in genetic cerebral
small vessel disease, and NOAC concentration in stroke prevention, among other areas. His related work
has been published in highly cited and competitive international journals.
Stroke Center at National Taiwan University Hospital. Dr. Tang received his MD from the College of
Medicine and his PhD from the Graduate Institute of Clinical Medicine at National Taiwan University.
After completing his neurology residency training at NTUH, he participated in a two-year exchange
program in the laboratory of Professor Mark P. Mattson at the National Institute on Aging, NIH, during
2005-2006. In addition to his basic stroke research, Dr. Tang has a strong interest in genetic cerebral
small vessel disease, and NOAC concentration in stroke prevention, among other areas. His related work
has been published in highly cited and competitive international journals.
[S-07-2]Intracerebral hemorrhages in CADASIL
Jay Chol Choi (Department of Neurology, Jeju National University, Korea)
Professor of Neurology, College of Medicine, Jeju National University
Professor of Neurology, Department of Neurology, Jeju National University Hospital
Director, Institute for Medical Science, Jeju National University
Editor-in-chief, Journal of Medicine and Life Science
Director, Clinical Practice Guideline Committee, Korean Stroke Society
Chairman, Korean Stroke Genomics Research Council
1. Education Background(s):
Korea University, College of Medicine 1989 - 1995 MD 1995
Korea University 1996 - 1999 MS 1999 (Majoring in Neuroscience)
Korea University 1999 - 2004 PhD 2008 (Majoring in Neuroscience)
Neurology resident at Korea University Hospital 1996-1999
Fellowship in Cerebrovascular disease at Korea University Hospital 2003
2. Positions, Scientific Appointments, and Honors
Positions:
2009-2014 Director, Regional Cerebrovascular center at Jeju National University Hospital Regional Cerebrovascular center
2014-2019 Director, Jeju National University Hospital Regional CardioCerebrovascular center
2012-Current Editorial board, Journal of Stroke
2012-2014
Visiting professor of Neurology at UC San Francisco, Stroke center
2004-Current Professor of Neurology, Department of Neurology, Jeju National University Hospital
2020-Current Director, Institute for Medical Science, Jeju National University
2020-Current Editor-in-chief, Journal of Medicine and Life Sciences
2023-Current Director, Clinical Practice Guideline Committee, Korean Stroke Society
Professor of Neurology, Department of Neurology, Jeju National University Hospital
Director, Institute for Medical Science, Jeju National University
Editor-in-chief, Journal of Medicine and Life Science
Director, Clinical Practice Guideline Committee, Korean Stroke Society
Chairman, Korean Stroke Genomics Research Council
1. Education Background(s):
Korea University, College of Medicine 1989 - 1995 MD 1995
Korea University 1996 - 1999 MS 1999 (Majoring in Neuroscience)
Korea University 1999 - 2004 PhD 2008 (Majoring in Neuroscience)
Neurology resident at Korea University Hospital 1996-1999
Fellowship in Cerebrovascular disease at Korea University Hospital 2003
2. Positions, Scientific Appointments, and Honors
Positions:
2009-2014 Director, Regional Cerebrovascular center at Jeju National University Hospital Regional Cerebrovascular center
2014-2019 Director, Jeju National University Hospital Regional CardioCerebrovascular center
2012-Current Editorial board, Journal of Stroke
2012-2014
Visiting professor of Neurology at UC San Francisco, Stroke center
2004-Current Professor of Neurology, Department of Neurology, Jeju National University Hospital
2020-Current Director, Institute for Medical Science, Jeju National University
2020-Current Editor-in-chief, Journal of Medicine and Life Sciences
2023-Current Director, Clinical Practice Guideline Committee, Korean Stroke Society
[S-07-3]New Disease Concept "Pro-hemorrhagic CADASIL"
Satoshi Saito, Hiroyuki Ishiyama, Masafumi Ihara (Department of Neurology, National Cerebral and Cardiovascular Center, Japan)
Dr. Satoshi Saito is the Chief Physician of the Department of Neurology at the National Cerebral and Cardiovascular Center in Japan, specializing in translational research in neurology. His research focuses on elucidating the pathophysiology of cerebral small vessel diseases and developing novel therapeutic approaches for CADASIL and CAA. After receiving his PhD from Kyoto University in 2017, Dr. Saito conducted postdoctoral research under the supervision of Dr. Masafumi Ihara at the National Cerebral and Cardiovascular Center. From 2019 to 2021, he continued his postdoctoral work under the guidance of Prof. Roxana Carare and Prof. Roy Weller at the University of Southampton in the UK. Since 2021, he resumed his research in collaboration with Dr. Ihara in Japan. Dr. Saito holds seven patents and has authored 75 peer-reviewed research articles, including 20 as the first author. He has received multiple awards, including the Japan Stroke Society Award 2017.
[S-07-4]Clinical features of cerebral hemorrhage due to COL4A1/2 mutations
Akihiko Ueda1, Satoru Shinriki2, Makoto Nakajima1, Mitsuharu Ueda1 (1.Department of Neurology, Faculty of Life Science, Kumamoto University, Japan, 2.Department of Molecular Laboratory Medicine, Faculty of Life Science, Kumamoto University, Japan)
2001 Graduated from Kumamoto University School of Medicine
2016 Assistant Professor, Department of Neurology, Kumamoto University Hospital
2023 Clinical Lecturer, Department of Neurology, Kumamoto University Hospital
2016 Assistant Professor, Department of Neurology, Kumamoto University Hospital
2023 Clinical Lecturer, Department of Neurology, Kumamoto University Hospital
[S-07-5]Hemorrhagic phenotype of cerebral small vessel disease associated with ABCC6 mutations
Sho Kitahara1, Shoichiro Ando1, Masahiro Uemura1, Yuya Hatano1, Hiroaki Nozaki2, Tomohiko Ishihara1,3, Osamu Onodera1 (1.Department of Neurology, Brain Research Institute, Niigata University, Japan, 2.Department of Medical Technology, Graduate School of Health Sciences, Niigata University, Japan, 3.Advanced Treatment of Neurological Diseases Branch, Endowed Research Branch, Brain Research Institute, Niigata University, Japan)
Graduated from the Faculty of Medicine, Niigata University, in 2016.
Joined the Department of Neurology, Brain Research Institute, Niigata University, in 2019.
Expected to complete the PhD program in the Department of Neurology, Brain Research Institute, Niigata University, in 2025.
Joined the Department of Neurology, Brain Research Institute, Niigata University, in 2019.
Expected to complete the PhD program in the Department of Neurology, Brain Research Institute, Niigata University, in 2025.