Session Details
[S-20]Symposium 20 Recent advances in treating axial symptoms in Parkinson's disease
Thu. May 22, 2025 3:10 PM - 5:10 PM JST
Thu. May 22, 2025 6:10 AM - 8:10 AM UTC
Thu. May 22, 2025 6:10 AM - 8:10 AM UTC
第02会場(大阪国際会議場5F 小ホール)
Chairs: Masahito Mihara（Kawasaki Medical School, Japan）, Yohei Mukai（Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Japan）
The axial symptoms in Parkinson's disease, such as postural instability and gait impairment, have been recognized as factors leading to a decline in activities of daily living and quality of life. These symptoms were considered to have low responsiveness to medication and its treatment was challenging. However, recent advances in understanding the pathophysiology of axial symptoms have led to exploration of new treatment approaches, including exercise therapy and brain stimulation therapy. In this symposium, we would like to introduce the latest findings on the pathophysiology and novel treatment challenges for axial symptoms in Parkinson's disease.
[S-20-1]Physiological underpinnings of gait and postural abnormality in Parkinson's disease
Kaoru Takakusaki (Asahikawa Medical University, Japan)
March 1984: Graduated from Asahikawa Medical University
March 1988: PhD degree at Asahikawa Medical University
April 1988: Assistant professor at Asahikawa Medical University
April 1991: Lecturer at Asahikawa Medical University
March 1993: Postdoctoral research fellow at the University of Tennessee School of Medicine (~March 1995)
November 1998: Associate Professor at Asahikawa Medical University
September 2009: Visiting Associate Professor at the National Institute for Physiological Sciences (~November 2008)
September 2010: Professor at Asahikawa Medical University (~ March 2025)
October 2011: Professor at the University of Tokyo Graduate School of Engineering (~ March 2013)
April 2025 Professor Emeritus of Asahikawa Medical University
April 2025 Visiting professor at the University of Tokyo Graduate School of Engineering
March 1988: PhD degree at Asahikawa Medical University
April 1988: Assistant professor at Asahikawa Medical University
April 1991: Lecturer at Asahikawa Medical University
March 1993: Postdoctoral research fellow at the University of Tennessee School of Medicine (~March 1995)
November 1998: Associate Professor at Asahikawa Medical University
September 2009: Visiting Associate Professor at the National Institute for Physiological Sciences (~November 2008)
September 2010: Professor at Asahikawa Medical University (~ March 2025)
October 2011: Professor at the University of Tokyo Graduate School of Engineering (~ March 2013)
April 2025 Professor Emeritus of Asahikawa Medical University
April 2025 Visiting professor at the University of Tokyo Graduate School of Engineering
[S-20-2]Recent advances in non-invasive neuromodulation for gait disturbance in Parkinson's disease
Satoko Koganemaru (Department of Rehabilitation Medicine, Osaka Medical and Pharmaceutical University, Japan)
2005 Graduated from School of Medicine, Kyoto University, Japan
2010 Completed PhD in Rehabilitation Science, Higher Neural Control Systems, Graduate School of Medicine, Hyogo Medical University, Japan
2013 JSPS Postdoctoral Research Fellow, Graduate School of Medicine, Kyoto University, Japan
2017 Assistant Professor, Department of Rehabilitation, Hokkaido University Hospital, Japan
2019 Associate Professor, Department of Physiology, School of Medicine, Dokkyo Medical University, Japan
2021 Specific Associate Professor, Department of Regenerative Systems Neuroscience, Human Brain Research Center, Graduate School of Medicine, Kyoto University
2024-Present, Associate Professor, Department of Rehabilitation Medicine,
Osaka Medical and Pharmaceutical University
2010 Completed PhD in Rehabilitation Science, Higher Neural Control Systems, Graduate School of Medicine, Hyogo Medical University, Japan
2013 JSPS Postdoctoral Research Fellow, Graduate School of Medicine, Kyoto University, Japan
2017 Assistant Professor, Department of Rehabilitation, Hokkaido University Hospital, Japan
2019 Associate Professor, Department of Physiology, School of Medicine, Dokkyo Medical University, Japan
2021 Specific Associate Professor, Department of Regenerative Systems Neuroscience, Human Brain Research Center, Graduate School of Medicine, Kyoto University
2024-Present, Associate Professor, Department of Rehabilitation Medicine,
Osaka Medical and Pharmaceutical University
[S-20-3]Deep brain stimulation for axial symptoms in Parkinson's disease
Takashi Tsuboi (Nagoya University, Department of Neurology, Japan)
Dr. Takashi Tsuboi is an Assistant Professor in the Department of Neurology at Nagoya University. He graduated from Nagoya University School of Medicine in 2005 and earned his Ph.D. from the Department of Neurology at Nagoya University Graduate School of Medicine in 2015.
Dr. Tsuboi's research focuses on Parkinson's disease, tremor, deep brain stimulation, and speech disorders. From 2018 to 2020, he served as a research fellow at the University of Florida's Fixel Institute for Neurological Diseases, where he contributed to advancements in deep brain stimulation research. He has authored over 60 peer-reviewed publications in these areas.
Dr. Tsuboi is actively involved in the International Parkinson and Movement Disorder Society, serving as a member of the Awards Committee, the Steering Committee of the Speech and Movement Disorders Study Group, and the Education Committee of the MDS Asian and Oceanian Section.
Dr. Tsuboi's research focuses on Parkinson's disease, tremor, deep brain stimulation, and speech disorders. From 2018 to 2020, he served as a research fellow at the University of Florida's Fixel Institute for Neurological Diseases, where he contributed to advancements in deep brain stimulation research. He has authored over 60 peer-reviewed publications in these areas.
Dr. Tsuboi is actively involved in the International Parkinson and Movement Disorder Society, serving as a member of the Awards Committee, the Steering Committee of the Speech and Movement Disorders Study Group, and the Education Committee of the MDS Asian and Oceanian Section.
[S-20-4]Treatment strategy for Camptocormia in Parkinson's disease
Yohei Mukai, Yuji Takahashi (Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry Hospital, Japan)
Curriculum Vitae
2022- Head physician in Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry Hospital
2014-2022 Medical Staff, Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry Hospital
2013-2014 Medical Staff, Department of Neurology, Tokushima Prefectural Central Hospital
2011-2013 Senior Resident, Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry Hospital
2007-2014 Enrolled in the Graduate School of Tokushima University
2004-2007 Resident in Department of Neurology, Kameda General Hospital
2003-2004 Resident in Department of Neurology, Tokushima University Hospital
2003 Graduated from the Faculty of Medicine, Tokushima University
2022- Head physician in Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry Hospital
2014-2022 Medical Staff, Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry Hospital
2013-2014 Medical Staff, Department of Neurology, Tokushima Prefectural Central Hospital
2011-2013 Senior Resident, Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry Hospital
2007-2014 Enrolled in the Graduate School of Tokushima University
2004-2007 Resident in Department of Neurology, Kameda General Hospital
2003-2004 Resident in Department of Neurology, Tokushima University Hospital
2003 Graduated from the Faculty of Medicine, Tokushima University
[S-20-5]Rehabilitative treatment for axial symptoms in Parkinson's disease
Margaret Kit Yi Mak (Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China)
Prof. Mak is currently an Adjunct Professor at the Department of Rehabilitation Sciences of The Hong Kong Polytechnic University. She graduated as a physiotherapist and obtained her PhD from Curtin University of Technology, Australia. Her research focuses on rehabilitation of people with Parkinson’s disease. Based on the understanding of the mechanisms underlying balance and functional problems, she has developed innovative fall prevention programs with the use of augmented audio-visual cues, technology-assisted training, and added cognitive and motor tasks. Prof. Mak also applied non-invasive brain stimulation to augment the effect of gait training and to examine the neurophysiological mechanism underlying gait freezing. Prof. Mak serves on the Physiotherapists Board of Hong Kong and is the council member of the Hong Kong Parkinson’s disease Foundation.