[1P] Poster

[1P-378] Elucidating Failure of the SSBP1–HSF1 Axis and Mitochondrial Proteostasis Disruption in Kii ALS/PDC by Multi-omics and Histological Analyses

*Moe Kobayashi^1,2, Chris Kato^2,3, Satoru Morimoto^2,3,4, Yuhko Kobayashi⁵, Masako Ichishi⁴, Yoshifumi Hirokawa⁴, Issei Kobayashi⁵, Terunori Sano⁶, Maho Morishima^6,7, Masaki Takao⁶, Yuko Saito⁷, Mari Yoshida⁸, Shigeo Murayama⁷, Hideyuki Okano², Yasumasa Kokubo⁹ (1. Faculty of Pharmacy, Keio University, Tokyo, Japan, 2. Keio Regenerative Medicine Research Center, Keio University, Japan, 3. Division of Neurodegenerative Disease Research, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Japan, 4. Department of Oncologic Pathology, Mie University Graduate School of Medicine, Japan, 5. Center for Molecular Biology and Genetics, Mie University, Japan, 6. Department of Clinical Laboratory and Internal Medicine, National Center of Neurology and Psychiatry (NCNP), National Center Hospital, Japan, 7. Department of Neuropathology (the Brain Bank for Aging Reseach, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Japan, 8. Institute for Medical Science of Aging, Aichi Medical University, Japan, 9. Kii ALS/PDC Research Centre, Mie University Graduate School of Regional Innovation Studies, Japan)

Keywords:

Kii ALD/PDC,Mitochondria,proteostasis,Multi-omics

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