[1S03m] The Multilayered Role of the Nuclear Lamina in Brain Formation, Disease, and Aging

[1S03m-02] Lamin B1 physically regulates neuronal migration by modulating nuclear deformability in the developing cortex

*Minkyung Shin¹, Shunichi Ishida², Jinseon Yu^3,4, Misato Iwashita¹, Gyeong-un Jang¹, Pietro Cortelli⁵, Elisa Giorgio^6,7, Ilaria Cani⁸, Giulia Ramazzotti⁹, Stefano Ratti⁹, Daisuke Yoshino¹⁰, Jong-Cheol Rah^3,4, Yohsuke Imai², Yoichi Kosodo^1,4 (1. Neural Regeneration Laboratory, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea, 2. Graduate School of Engineering, Kobe University, Kobe, Japan, 3. Neurophysiology Laboratory, KBRI, Daegu, Republic of Korea, 4. Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea, 5. Alma Mater Studiorum, University of Bologna, Bologna, Italy, 6. Department of Molecular Medicine, University of Pavia, Pavia, Italy , 7. IRCCS Mondino Foundation, Neurogenetics Research Centre, Pavia, Italy, 8. U.O.C. Clinica Neurologica Rete Metropolitana (NeuroMet), IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, 9. Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy, 10. Division of Advanced Applied Physics, Institute of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan)

Keywords:

Lamin B1 (LB1),neuronal migration,cortical development,physical microenvironment

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