Presentation Information

[2P-027]Astrocytic Dysfunction Impairs Dopaminergic Neuronal Survival and Activity in LRRK2 I1371V Parkinson’s Disease: Recovery Through GTPase Inhibition

*Roon Banerjee1, Mokshada Balaskar1, Vikram Holla2, Nitish Kamble2, Ravi Yadav2, Pramod Kumar Pal2, Indrani Datta3 (1. Department of Biophysics , National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029., 2. Department of Neurology, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029., 3. Correspondence: indranidatta.nimhans@gmail.com, Department of Biophysics , National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029.)

Keywords:

Parkinson's Disease LRRK2 GTPase mutation,Electrophysiology,Inflammatory signature,Vesicular Dopamine release

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