[2P] Late-Breaking Abstracts

[2P-435] MRI-guided focused ultrasound combined with intravenous AAV for spatially targeted therapy in mice with tauopathy and with intra-CSF AAV for transduction of superficial and deep brain regions in rats and non-human primates

*Isabelle Aubert¹, Laura Vecchio¹, Nazia Habib², Alessia Apa¹, Kate Noseworthy¹, Sheng-Kai Wu¹, Luis Fernando Rubio-Atonal¹, Nathalie Vacaresse¹, Shawna Rideout¹, Brandy Laurette¹, Luca Giliberto^2,3,4, Kullervo Hynynen¹, Cristina D'Abramo^2,3, For FUS AVV-ICM in rats and NHPs, the author list is provided at doi.org/10.1016/j.ymthe.2026.02.021^1,5,6 (1. Sunnybrook Research Institute, University of Toronto, Toronto, Canada, 2. Feinstein Institutes for Medical Research, The Litwin-Zucker Center for Alzheimer’s Disease & Memory Disorders, Institute of Molecular Medicine, Manhasset, United States of America, 3. Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, United States of America, 4. Northwell Health, Institute for Neurology and Neurosurgery, Manhasset, United States of America, 5. Aarhus University, Department Of Clinical Medicine, Aarhus N, Denmark, 6. Sanofi, United States of America)

Keywords:

Targeted AAV brain delivery,Neurodegenerative disorders: Alzheimer's disease,Parkinson's disease,tauopathy,Focused Ultrasound,Gene Therapy

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