[3P] Poster

[3P-396] Co-translational aggregation of nascent polypeptides in neurodegenerative disorders

*Ryo Endo¹, Aki Endo-Murayama¹, Noriko Takashima¹, Yuko Saito², Takashi Komori³, Keisuke Ishizawa³, Koshi Imami⁴, Hideki Taguchi⁵, Motomasa Tanaka¹ (1. Lab for Protein Conformation Diseases, RIKEN Center for Brain Science, 2. Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 3. Tokyo Metropolitan Neurological Hospital, 4. Proteome Homeostasis Research Unit, Center for Integrative Medical Sciences, RIKEN, 5. Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo)

Keywords:

Ribosome stalling,co-translational protein aggregation,NOTCH2NLC GGC repeat expansions,neuronal intranuclear inclusion disease

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