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Pathology of synapse-proteasome signaling in Alzheimer disease and aging

With the advent of a super-aging society, the increase in age-related diseases has become a social problem. The causes of aging-dependent loss of neuronal function are still unknown. We have identified a signaling network and novel regulatory systems focusing on unique biomarkers to understand how homeostasis of neural function is maintained and lost. In this symposium, we will review the latest data on the regulatory mechanisms of neuronal homeostasis and discuss their physiological significance in disease and their therapeutic applications.

Frontiers in neuronal homeostasis in aging and neurodegenerative diseases This symposium was supported by the AMED Strategic Promotion Program for Translational Research, the Takeda Science Foundation for Pharmaceutical Research Continuous Grants, and the Tohoku University Young Leaders Overseas Program.

The 46th Annual Meeting of the Japan Neuroscience Society

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[1S10a-05]Pathology of synapse-proteasome signaling in Alzheimer disease and aging

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