[2P] Poster

[H. Disorders of Nervous Systems] Alzheimer's Disease and Dementia

[2P-221] Alcadein α-deficient humanized APP-KI mice exhibit augmented amyloidogenic APP metabolism, increased Aβ accumulation, and enhanced plaque load during aging

*Tohru Yamamoto¹, Keiko Honda², Hiroo Takahashi¹, Saori Hata^2,3, Ruriko Abe², Takashi Saito⁴, Takaomi C Saido⁵, Hidenori Taru², Yuriko Sobu^2,6, Kanae Ando⁷, Toshiharu Suzuki^2,7 (1. Fac Med, Kagawa Univ, Miki-cho, Japan, 2. Grad Sch Pharm, Hokkaido Univ, Sapporo, Japan, 3. Bioprod Res Inst, AIST, Sapporo, Japan, 4. Grad Sch Med, Nagoya City Univ, Nagoya, Japan, 5. RIKEN CBS, Wako, Japan, 6. Grad Sch Brain Sci, Doshisha Univ, Kyotanabe, Japan, 7. Grad Sch Sci, Tokyo Metropolitan Univ, Hachioji, Japan)

Keywords:

APP,Alcadein,Aβ,amyloidogenic metabolism

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