[2P] Late-Breaking Abstracts

[H. Disorders of Nervous Systems] Neurodegenerative Disorders

[2P-386] Balancing efficacy and ototoxicity in 2-hydroxypropyl-β-cyclodextrin therapy for Niemann-Pick disease type C by degree and pattern of substitution

*Mayuko Tanaka¹, Akira Ishii¹, Yusei Yamada², Yuki Kondo³, Toru Miwa⁴, Hiroki Takeda⁵, Yorihisa Orita⁵, Toru Takeo⁶, Naomi Nakagata⁶, Taishi Higashi³, Keiichi Motoyama³, Hidetoshi Arima⁷, Takahiro Seki⁸, Yuki Kurauchi³, Hiroshi Katsuki³, Ryuji Ikeda², Katsumi Higaki⁹, Muneaki Matsuo¹⁰, Tetsumi Irie³, Yoichi Ishitsuka³ (1. Grad Sch Pharm, Univ of Kumamoto, Kumamoto, Japan, 2. Dept of Pharm, Univ of Miyazaki Hospital, Miyazaki, Japan, 3. Grad Sch Life Sci, Univ of Kumamoto, Kumamoto, Japan, 4. Dept of Otorhinolaryngology, Mizoguchi Hospital, Univ of Teikyo, Kawasaki, Japan, 5. Dept of Otorhinolaryngology, Faculty of Medicine, Univ of Kumamoto, Kumamoto, Japan, 6. Ctr for Life Resource Development, Univ of Kumamoto, Kumamoto, Japan, 7. Fac Pharm Sci, Univ of Daiichi Pharmacy, Fukuoka, Japan, 8. Fac Pharm Sci, Univ of Himeji Dokkyo, Himeji, Japan, 9. Ctr for Research Infrastructure, Univ of Tottori, Tottori, Japan, 10. Dept of Pediatrics, Univ of Saga Hospital, Saga, Japan)

Keywords:

Niemann-Pick disease type C,2-hydroxypropyl-β-cyclodextrin,Degree of substitution

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