[3P] Poster

[H. Disorders of Nervous Systems] Neurodegenerative Disorders

[3P-245] Elucidation of the mechanism of mutant AR aggregate formation in spinal and bulbar muscular atrophy (SBMA) using disease-specific iPSCs.

*Kimihiko Sasaki¹, Kazunari Onodera^1,2, Himari Ogiwara¹, Reika Sobue¹, Fumito Yoshii¹, Soma Koten¹, Yu-Shen Cheng¹, Yukiko Kitashiba¹, Masahisa Katsuno², Gen Sobue³, Hideyuki Okano⁴, Yohei Okada¹ (1. Dept Neural iPSC Res, Inst for Med Sci of Aging, Aichi Med Univ, 2. Dept Neurol, Nagoya Univ Grad Sch of Med, 3. Aichi Med Univ, 4. Keio Univ Regen Med Res Ctr)

Keywords:

Spinal and bulbar muscular atrophy,SBMA,induced pluripotent stem cells,iPSCs,Androgen receptor,nucleocytoplasmic transport

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