The 140th Annual Meeting of the Pharmaceutical Society of Japan (Kyoto)
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Session Details

Oral Presentation(A) Organic Chemistry

[26J-am]医薬品設計・構造活性相関①

Thu. Mar 26, 2020 9:00 AM - 11:36 AM JST
Thu. Mar 26, 2020 12:00 AM - 2:36 AM UTC
[Room J] Room J 2F
Chair: Mizuki Watanabe, Takaaki Sumiyoshi
9:00 AM - 9:12 AM JST(12:00 AM - 12:12 AM UTC)

[26J-am01S]Synthesis of modulators for short-chain fatty acid receptors as new potential therapeutic targets

○Daiki Nishiyama1, Ken-ichi Iwamoto1, Atsukazu Kuwahara2, Yasutada Akiba3, Jonathan D. Kaunitz3, Kei Manabe1 (1. University of Shizuoka, 2. Ritsumeikan University, 3. University of California, Los Angeles)
9:12 AM - 9:24 AM JST(12:12 AM - 12:24 AM UTC)

[26J-am02S]Development of novel TGR5 ligands

○Ryusei Terui1,2, Takashi Misawa2, Yoshitomo Suhara1, Yosuke Demizu2,3 (1. Coll. of Systems Engineering and Sci., Shibaura Institute of Technology., 2. NIHS, 3. Grad Sch. Med. Life Sci., Yokohama city Univ.)
9:24 AM - 9:36 AM JST(12:24 AM - 12:36 AM UTC)

[26J-am03S]Design of polyunsaturated fatty acid surrogates from conformational analysis

○Mian Wu1, Misa Sayama1, Mariko Hayashi2, Kaoru Sato3, Kanako Takahashi3, Yuko Otani1, Tomohiko Ohwada1 (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo, 2. Med., Int. Univ. Health & Welfare, 3. NIHS)
9:36 AM - 9:48 AM JST(12:36 AM - 12:48 AM UTC)

[26J-am04S]Generation of Antagonists toward a Lipid Ligand, Lysophosphatidylserine Specific G Protein-coupled Receptor

○Misa Sayama1, Masaya Ikubo1, Luying Chen1, Ge Yan1, Yuko Otani1, Akiharu Uwamizu2, Asuka Inoue2, Junken Aoki2, Tomohiko Ohwada1 (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo, 2. Grad. Sch. Pharm. Sci., Tohoku Univ.)
9:48 AM - 10:00 AM JST(12:48 AM - 1:00 AM UTC)

[26J-am05S]Examination and Validation of Hydrophobic Interactions in P2Y10-Ligand Binding, Based on Simulation-Aided Structure-Activity-Relationship Analysis

○Luying Chen1, Misa Sayama1, Yuko Otani1, Akiharu Uwamizu2, Asuka Inoue2, Junken Aoki2, Tomohiko Ohwada1 (1. Grad. Sch. Pharm. Sci., Univ. of Tokyo, 2. Grad. Sch. Pharm. Sci., Tohoku Univ.)
10:00 AM - 10:12 AM JST(1:00 AM - 1:12 AM UTC)

[26J-am06S]Structural Optimization of Non-Naturally Occurring Helical Molecules Which Can Interfere with p53-MDM2 / MDMX Protein-Protein Interactions

○Aoze Su1, Siyuan Wang1, Akane Sada2, Yuko Otani1, Rieko Ohki2, Tomohiko Ohwada1 (1. Grad. Sch. Pharm. Sci., the Univ. of Tokyo, 2. Natl. Cancer Ctr. Res. Inst.)
10:12 AM - 10:24 AM JST(1:12 AM - 1:24 AM UTC)

[26J-am07S]Design and synthesis of carborane-based PPI controlling agents by mimicking peptide binding epitopes

○Yasunobu Asawa1,2, Atsushi Yoshimori3, Kentaro Yamada4, Shao Yujie5, Li Guangzhe5, Akira Katoh4,6, Hiroyuki Kouji4,6, Hiroyuki Nakamura1 (1. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Tech., 2. School of Life Science and Technology, Tokyo Tech., 3. ITM, Inc., 4. Faculty of Medicine, Oita Univ., 5. Dalian University of Technology, 6. Oita University Institute of Advanced Medicine, Inc.)
10:24 AM - 10:36 AM JST(1:24 AM - 1:36 AM UTC)

[26J-am08S]Development of antibacterial stapled-peptide foldamer

○Motoharu Hirano1, Chihiro Goto1,2, Katsuhiko Hayashi1, Yutaka Kikuchi1, Takashi Misawa1, Yukiko Hara-Kudo1, Yosuke Demizu1,2 (1. NIHS, 2. Grad. Sch. Med. Life Sci., Yokohama city Univ.)
10:36 AM - 10:48 AM JST(1:36 AM - 1:48 AM UTC)

[26J-am09S]Development of Long-lasting Stapled Peptides Targeting BIG3-PHB2 Interaction in Breast Cancer Cell

○Keitaro Anyoji1, Keisuke Aihara1, Tetsuro Yoshimaru2, Yusuke Nishikawa1, Masato Komatsu2, Akira Shigenaga1, Toyomasa Katagiri2, Akira Otaka1 (1. Grad. Sch. Pharm. Sci., Tokushima Univ., 2. Inst. Genome Res., Tokushima Univ.)
10:48 AM - 11:00 AM JST(1:48 AM - 2:00 AM UTC)

[26J-am10S]Enzymatic stability of myostatin inhibitory peptides

○Miki ODAGIRI1, Kentaro TAKAYAMA1,2, Akihiro TAGUCHI1, Atsuhiko TANIGUCHI1, Yoshio HAYASHI1 (1. Tokyo Univ. Pharm. Life Sci. , 2. Kyoto Pharm. Univ.)
11:00 AM - 11:12 AM JST(2:00 AM - 2:12 AM UTC)

[26J-am11S]Synthesis of novel compounds aimed at DOR biased agonist

○yuichi sato1, Hirayama Shigeto1, Fujii Hideaki1 (1. Grad. sch. Pharm. Kitasato Univ.)
11:12 AM - 11:24 AM JST(2:12 AM - 2:24 AM UTC)

[26J-am12S]Design and synthesis of the novel delta opioid receptor agonist

11:24 AM - 11:36 AM JST(2:24 AM - 2:36 AM UTC)

[26J-am13S]Structure–ATPase activity relationship of rhodamine derivatives as transport substrates for P-glycoprotein CmABCB1

Hiroshi Takikawa1, ○Sorachi Miwa1, Yamaoka Yosuke1, Tomohiro Yamaguchi1, Toru Nakatsu1, Hiroaki Kato1, Kiyosei Takasu1 (1. Grad. Sch. Pharm. Sci., Kyoto Univ.)
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