Session Details
[S17]A multi-faceted approach to dementia treatment by young researchers
Thu. Mar 26, 2020 4:15 PM - 6:15 PM JST
Thu. Mar 26, 2020 7:15 AM - 9:15 AM UTC
Thu. Mar 26, 2020 7:15 AM - 9:15 AM UTC
[Room U] Swan 1F
Organizers: Yuki Takada-Takatori (Fac Pharm Sci, Doshisha Women's Coll Lib Arts), Satoshi Okuyama (Coll Pharm Sci, Matsuyama Univ)
In an aging society with an extended life expectancy, dementia has become a major public health problem, and the number of patients with dementia continues to increase. There are high unmet medical needs (medical needs that have not been satisfied yet) for dementia, and a drug discovery for fundamental treatment is essential to move beyond current symptomatic treatment. In addition, as a countermeasure against dementia, the Japanese government strongly promotes strategies that prevent, delay the onset of, and suppress the progression of dementia. However, development of new mechanisms underlying dementia treatment and prevention have not been successful so far, and drug discovery targets from a new perspective are required.
In this symposium, six speakers from pharmacology, physical chemistry, bioanalytical chemistry, pharmacokinetics, and pharmacotherapeutics will discuss the development of new therapeutic drugs and the establishment of diagnosis and prevention methods across various fields. In addition, perspectives of future dementia research, drug discovery applications, and drug development will be discussed. Through this symposium, our goals are to share multidisciplinary approaches to dementia research, expand our research capabilities, and discover new mechanisms of action that can lead to the development of innovative new therapeutic and preventive treatments for dementia.
In this symposium, six speakers from pharmacology, physical chemistry, bioanalytical chemistry, pharmacokinetics, and pharmacotherapeutics will discuss the development of new therapeutic drugs and the establishment of diagnosis and prevention methods across various fields. In addition, perspectives of future dementia research, drug discovery applications, and drug development will be discussed. Through this symposium, our goals are to share multidisciplinary approaches to dementia research, expand our research capabilities, and discover new mechanisms of action that can lead to the development of innovative new therapeutic and preventive treatments for dementia.
[S17-Opening]Opening remarks
Satoshi Okuyama1 (1. Coll Pharm Sci, Matsuyama Univ)
[S17-1]Search for citrus components with neuroprotective and anti-dementia effect in the mouse brain
○Satoshi Okuyama1, Atsushi Sawamoto1, Mitsunari Nakajima1, Yoshiko Furukawa1 (1. Col. Pharm. Sci., Matsuyama Univ.)
[S17-2]Cell-surface initial aggregation process of amyloid-β peptides studied by fluorescence correlation spectroscopy
○Yoshiaki Yano1 (1. Grad Sch Pharm Sci, Kyoto Univ)
[S17-3]Pharmacokinetics/pharmacodynamic modeling to link pharmacokinetics to efficacy and drug interaction of Alzheimer's disease drugs
Shugo Yamashita1, Shunsuke Kimura1, ○Akiko Kiriyama1 (1. Fac Pharm Sci, Doshisha Women's Coll Lib Arts)
[S17-4]Mapping the metallo-maze to memory loss: Does neuronal metal ion deficiency contribute to dementia?
○Mark J. Hackett1,2,3, Ashley Hollings1,2,3, Virginie Lam2, Ryu Takechi2, John C.L. Mamo2, Martin D. de Jonge4, David Paterson4 (1. Sch Mol Life Sci, Curtin Univ, 2. Curtin Health Innov Res Inst, 3. Curtin Inst Funct Mol Interfaces, 4. Australian Synchrotron, ANSTO)
[S17-5]Type II diabetes mellitus is an accelerating factor of Alzheimer's disease
○Naotaka Izuo1 (1. Grad Sch Pharm Sci, Univ Toyama)
[S17-6]Donepezil reduces amyloid precursor protein endocytosis by resulting from increase in the expression of sorting nexin protein 33
○Yuki Takada-Takatori1, Yumiko Mizukawa1, Tetsuro Urushidani1, Yasuhiko Izumi2,3, Akinori Akaike2,4, Katsuharu Tsuchida1, Toshiaki Kume2,5 (1. Fac Pharm Sci, Doshisha Women's Coll Lib Arts, 2. Grad Sch Pharm Sci, Kyoto Univ, 3. Kobe Pharm Univ, 4. Grad Sch Med, Wakayama Med Univ, 5. Grad Sch Med Pharm Sci, Univ Toyama)
[S17-Closing]Closing remarks
Yuki Takada-Takatori1 (1. Fac Pharm Sci, Doshisha Women’s Coll Lib Arts)
