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PK/PD evaluation of existing antimicrobials against ESBL-producing E. coli in in vitro and in vivo a murine thigh infection model

Antimicrobial-resistant bacteria are the cause of death in an estimated 700,000 people annually worldwide, and this number is predicted to increase to 10 million by 2050 if efforts are not made to reduce resistance or develop new antibiotics. Therefore, research, development, and proper use of antibiotics are urgent issues. However, development is decreasing, and misuse and abuse remain common, which lead to their spread. In this symposium, 6 young pharmaceutical scientists will present from varying backgrounds of infectious research (pre-clinical studies [PCS] ~ clinical studies [CS]). Young scientists who are actively trying to overcome the threat and improve clinical antibacterial chemotherapy will share novel medical seeds found in daily research and their opinions. These seeds are expected to advance both PCS and CS, which will aid in the development of new therapies. After this symposium, young scientists who are performing PCS and CS are anticipated to collaborate organically with each other to develop innovative next-generation treatments. We consider this symposium to be a shortcut to overcoming antimicrobial-resistant bacteria.

Young pharmaceutical scientists accelerate translational research in infectious disease

The 141st Annual Meeting of the Pharmaceutical Society of Japan (Hiroshima)

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[GS01-3]PK/PD evaluation of existing antimicrobials against ESBL-producing E. coli in in vitro and in vivo a murine thigh infection model

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