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Chemical approach for nucleic acid medicine

The term ‘foldamer’, which is an artificial oligomer molecule with a regular and constant secondary or tertiary structure, was coined by Prof. S. H. Gellman (University of Wisconsin, USA) in 1996.[1] More than 20 years have passed since then, various types of foldamers have been developed, and their unique structural characteristics have been clarified.[2] In addition, researches toward functionalization have been carried out energetically, and foldamers have the potential not only as tools for chemical biology research, but also as drug candidates.[3] In this symposium, there will be five pharmacy and non-pharmacy symposiasts in a well-balanced manner, and we will approach the attractiveness of foldamers from a wide variety of perspectives. In other words, we will discuss the possibility of foldamers for functionalization in a broad sense, from basic research to applied research for materials and drug discovery, with different molecules such as nucleic acids, peptides, and artificial helical molecules as building blocks. [1] S. H. Gellman et al., J. Am. Chem. Soc. 1996, 118, 13071. [2] G. Guichard, I. Huc, Chem. Commun. 2011, 47, 5933. [3] E. Valeur et al., J. Med. Chem. 2016, 59, 9599.

Attraction of foldamers

The 141st Annual Meeting of the Pharmaceutical Society of Japan (Hiroshima)

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[S14-1]Chemical approach for nucleic acid medicine

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