The 141st Annual Meeting of the Pharmaceutical Society of Japan (Hiroshima)
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Session Details

Symposium

[S05]Recent advances in the studies of metabolic syndromes and applications to the development of new drugs

Sat. Mar 27, 2021 1:15 PM - 3:15 PM JST
Sat. Mar 27, 2021 4:15 AM - 6:15 AM UTC
[Room D] Oral Presentation D Online
Organizer: Kushiyama Akifumi (Meiji Pharm. Univ.), Nakatsu Yusuke (Grad. Sch. Med., Hiroshima Univ.)
The area of ​​adult diseases, or lifestyle-related diseases has been emphasized as a target for drug discovery, and many epoch-making new drugs such as SGLT2 inhibitors have been developed and clinically applied in the last 10 years. However, that development is still far from controlling the disease. For example, type 2 diabetes, obesity, non-alcoholic steatohepatitis, sarcopenia, and overeating, still have many etiological and therapeutic challenges. Adult diseases are pathological conditions in which metabolic disorders are manifested as organ disorders, and in order to resolve them, it is necessary to deeply understand the metabolic regulation mechanism of the whole body, including the linkage of various organs from the basic aspect, and to elucidate the mechanism of metabolic disorders in various diseases such as obesity, diabetes, dyslipidemia and hyperuricemia.
At this symposium, researchers who are expected to be up-and-coming and leading researchers will introduce and discuss cutting-edge knowledge in each research area related to adult diseases. To make it easier for participants to systematically understand, the metabolism of major organs such as pancreas, liver, muscle, fat, blood vessels will be introduced, and the topic of new factors in the limelight will be discussed to reveal the pathophysiology of adult diseases. We hope this symposium will stimulate the research mind and be the beginning to meet the unmet medical needs related to adult diseases.
1:15 PM - 1:18 PM JST(4:15 AM - 4:18 AM UTC)

オーガナイザー挨拶：櫛山 暁史（明治薬大）

1:18 PM - 1:38 PM JST(4:18 AM - 4:38 AM UTC)

[S05-1]Functional manipulation of thermogenic adipocytes and its application for the treatment of lifestyle-related diseases

○Haruya Ohno1, Junji Sagawa1, Gentaro Egusa1, Gaku Nagano1, Kazuhiro Kobuke1, Kiyotaka Itcho1, Kenji Oki1, Masayasu Yoneda1 (1. Endocrinol. and Diabet. Med., Hiroshima Univ. Hosp.)
1:38 PM - 1:55 PM JST(4:38 AM - 4:55 AM UTC)

[S05-2]Prolyl isomerase Pin1 impacts on metabolism in muscle and adipocytes.

○Yusuke Nakatsu1,Tomoichiro Asano1 (1. Grad. Sch. of Med., Hiroshima Univ.)
1:55 PM - 2:15 PM JST(4:55 AM - 5:15 AM UTC)

[S05-3]Involvement of diacylglycerol kinase on the regulation of insulin secretion in pancreatic β-cells during type 2 diabetes.

○Yukiko Kaneko1, Tomohisa Ishikawa1 (1. Univ. Shizuoka, Sch. of Pharm. Sci.)
2:15 PM - 2:32 PM JST(5:15 AM - 5:32 AM UTC)

[S05-4]Metabolism-dependent vascular pathophysiology in adult diseases.

○Akifumi Kushiyama1, Masahiro Takahashi1, Sakura Kushiyama2, Takako Kikuchi3, Tomoichiro Asano4 (1. Meiji Pharm. Univ., 2. NCGM, 3. Inst. Adult Dis. Asahi Life Found., 4. Hiroshima Univ.)
2:32 PM - 2:52 PM JST(5:32 AM - 5:52 AM UTC)

[S05-5]Inhibition of plasminogen activator inhibitor-1 activation suppresses high fat diet-induced weight gain via alleviation of hypothalamic leptin resistance

○Tetsuya Yamada1, Shinichiro Hosaka2, Kei Takahashi2, Hideki Katagiri2 (1. Dep. of Mol. Endocrinol. and Metab., Tokyo Medical and Dental Univ., 2. Dep. of Metab. and Diabetes, Tohoku Univ.)
2:52 PM - 3:12 PM JST(5:52 AM - 6:12 AM UTC)

[S05-6]Role of fatty acid elongase Elovl6 in the regulation of fatty acid quality and lifestyle-related diseases

○Takashi Matsuzaka1,2, Hitoshi Shimano1 (1. Faculty of Med., Univ. of Tsukuba, 2. Transborder Med. Res. Center, Univ. of Tsukuba)
3:12 PM - 3:15 PM JST(6:12 AM - 6:15 AM UTC)

総括：中津 祐介（広島大院医系科学）

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