The 141st Annual Meeting of the Pharmaceutical Society of Japan (Hiroshima)
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Session Details

Poster Presentation(A) Organic Chemistry

[28P01]構造活性相関②

Sun. Mar 28, 2021 9:00 AM - 6:00 PM JST
Sun. Mar 28, 2021 12:00 AM - 9:00 AM UTC
[Room P01] Poster Presentation Online

[28P01-053S]Synthesis and biological evaluation of spirotenuipesine A derivatives

○Tsuyoshi Yanagimoto1, Sayo Yamada1, Yusuke Kasai1, Hirofumi Yamamoto1, Hiroshi Imagawa1 (1. Pharm. Sci., Tokushimabunri Univ.)

[28P01-054S]Development of nuclear receptor ligands bearing ferrocene as the hydrophobic pharmacophore

○Kotaro Ochiai1, Hiroyuki Kagechika1, Shinya Fujii1 (1. Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering)

[28P01-055S]Development of a high-throughput cell-based screen for squalene monooxygenase inhibitors based on ligand-mediated protein stabilization

○Tomoka Inoue1, Hiromasa Yoshioka2, Koji Kuramochi1, Kenji Ohgane1 (1. Tokyo Univ. of Science, 2. RIKEN)

[28P01-056S]Structure-activity relationships of sterols that induce proteasomal degradation of squalene monooxygenase

○Satoshi Katsuta1, Hiromasa Yoshioka2, Koji Kuramochi1, Kenji Ohgane1 (1. Tokyo Univ. of Science, 2. RIKEN)

[28P01-057S]Derivatization of amino group at 5-position of negamycin derivative for development of potent readthrough compound

○Chikashi Sawada1, Noriko Omura1, Keisuke Hamada1, Syo Konno1, Akihiro Taguchi1, Kentaro Takayama1,2, Atsuhiko Taniguchi1, Yoshio Hayashi1 (1. Sch.Pharm.,Tokyo Univ.Pharm.Life Sci, 2. Kyoto Pharmaceutical University)

[28P01-058S]Structure-activity relationship of 6-arylquinolone derivatives as novel PR antagonists

○Risa Sumida1, Mai Negishi1, Shuichi Mori2, Hiroyuki Kagechika2, Aya Tanatani1 (1. Grad. Sch. Adv. Sci., Ochanomizu Univ., 2. Inst. Biomater. Bioeng., Tokyo Med. Den. Univ.)

[28P01-059S]Structure-activity relationship study of anti-P. aeruginosa active uridylpeptide natural products

Yuma Terasawa1, Chisato Sataka1, Toyotaka Sato2, ○Kazuki Yamamoto1, Akira Katsuyama1, Takanori Matsumaru1,3, Fumika Yakushiji1, Shin-ichi Yokota2, Satoshi Ichikawa1,4 (1. Faculty of Pharmaceutical Sciences, Hokkaido Univ., 2. Sapporo Medical University, 3. Faculty of Science and Technology, Keio Univ., 4. GI-Core, Hokkaido Univ.)

[28P01-060S]Synthesis of 2'-deoxy carbocyclic nucleosides for anti-adenovirus agents

○Shinnosuke Arai1, Chiaki Saito1, Ayana Mizuishi1, Takashi Misawa2, Yousuke Demizu2, Masaaki kurihara1, Kiju Konno1 (1. International University of Health and Welfare Department of Pharmaceutical Sciences, School of Pharmacy, 2. National Institute of Health Sciences)

[28P01-061]Evaluation of inhibitory effect of thiazoryl coumarin derivatives on CYP19 activity

○Yuki Yamaguchi1, Ryohei Hasegawa1, Jun Mizuochi1, Yuichiro Hirayama1, Kenichi Kobayashi1 (1. Health Sciences University of Hokkaido)

[28P01-062]Synthesis of new T-type calcium channel inhibitors

○Hiroto Tanaka1,2, Isao Ooi1, Hideki Nakamura1, Toru Ogawa1, Tsuyoshi Endo1, Tomio Yamakawa1, Atsufumi Kawabata2 (1. Nippon Chemiphar Co., Ltd., 2. Faculty of Pharmacy, Kindai University)

[28P01-063S]Discovery of carbono(di)thioates as indoleamine 2,3-dioxygenase 1 inhibitors

Miyuki Kumazawa1, Manabu Tejima1, ○Shiori Toyama1, Miwa Fukuda2, Shota Takeda1, Hiroyuki Miyachi2, Akira Asai3, Osamu Takikawa4, Tomoko Hashimoto1, Osamu Ohno1, Kenji Matsuno1 (1. School of Advanced Engineering, Kogakuin University, 2. Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 3. Graduate School of Pharmaceutical Sciences, University of Shizuoka, 4. National Center for Geriatrics and Gerontology)

[28P01-064]Development of novel multi-target cell growth inhibitors based on m-carborane cage.

○Asako Kaise1, Yuya Yamashita1, Kiminori Ohta2, Yasuyuki Endo1 (1. Fac. Pharm. Sci. Tohoku Med. Pharm. Univ., 2. Sch. Pharm. Showa Univ.)

[28P01-065S]Structural development of water-soluble type 1 ryanodine receptor inhibitors

○XIKUN CHAI1, Hiroto Iinuma1, Shuichi Mori1, Mari Ishigami-Yuasa1, Takashi Murayama2, Nagomi Kurebayashi2, Hiroyuki Kagechika1 (1. Inst. Biomat. Bioeng. Tokyo Med. Dent. Univ., 2. Department of Pharmacology, Juntendo Univ. School of Medicine)

[28P01-066]Structural development of novel type 2 ryanodine receptor selective inhibitors

○Shuichi Mori1, Hiroto Iinuma1, Yuga Yamamoto1, Mari Ishigami-Yuasa1, Nagomi Kurebayashi2, Takashi Murayama2, Kagechika Hiroyuki1 (1. Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ, 2. Department of Parmacology, Juntendo Univ. School of Medicine)

[28P01-067S]Design and synthesis of highly active and low toxicity LCA derivatives as TGR5 agonists

○Takuto Koizumi1, Sunao Nishimura1, Yukiko Yamashita1, Daisuke Hino1, Go Masuda1, Yusuke Iguchi1, Mizuho Une1 (1. Faculty of Pharm. Sci., Hiroshima Int. Univ.)

[28P01-L002]Effect of HDAC inhibitors on the expression of the immune checkpoint protein PD-L1 in human breast cancer cells

○Hinata Nishino1, Yudai Takezawa1, Hiroya Anaguchi1, Yasuo Nagaoka1, Yoshiyuki Hirata2, Masahiko Taniguchi2, Shinichi Uesato1,2 (1. Fac. Chem. Mater. & Bioengineer., Kansai Univ., 2. Osaka Univ. of Pharm. Sci.)
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