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Molecular mechanism of T cell exhaustion by NR4a nuclear receptor and its reversion

At the 143rd Annual Meeting of the Pharmaceutical Society of Japan, the organizing committee members, Prof. Matsuda, Prof. Ogawa and Prof. Maenaka planned "Theme 2: Antibody Therapeutics and Immunology" as an interdisciplinary program "Connecting and Surpassing". Speakers who are conducting original research in the fields of immunology, drug discovery science, analytical chemistry, protein science, structural biology and virology are scheduled to give talks of advanced research on "antibody drugs and immunity", which are very important from the aspects of drug discovery and medical treatment methods. The first half of this program will focus on antibody therapeutics, with session 1 focusing on the development of approved antibody therapeutics (Opdivo and antibody-drug conjugate ADCs) in companies (Dr. Wagatsuma, Dr. Yoshida), as well as the basics of antibody therapeutics (Prof. Tsumoto) and the development process and prospects of antibody therapeutics (Dr. Ishii) will be introduced. Furthermore, Dr Hisataka Kobayashi (NIH) will give a special lecture on state-of-the-art photodiagnostic therapy. The second half of the day will comprise Session 2 on immune mechanisms, with Prof. Shizuo Akira (Research Institute for Microbial Diseases, Osaka University) giving a special lecture on the latest regulatory mechanisms of Toll-like receptors (TLR) signaling. The symposium in session 2 will introduce cytokine signaling (Prof. Yoshimura), structural analysis of TLRs (Prof. Shimizu), intestinal bacteria (Prof. Hase) and interferon responses (Prof. Takaoka). Through the two special lectures and symposia, the results of cutting-edge research will be widely shared from the perspective of antibody therapeutics and immunology, which will hopefully provide an impetus for new drug discovery and therapeutics, and lead to the development of pharmaceutical sciences.

Interdisciplinary Symposium “Antibody therapeutics/Immunology”

The 143rd Annual Meeting of the Pharmaceutical Society of Japan (Sapporo)

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[ISS02-05]Molecular mechanism of T cell exhaustion by NR4a nuclear receptor and its reversion

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