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Sulfur metabolism regulation and cytoprotection by NRF2

Supersulfides, in which sulfur atoms are catenated, are abundantly present in our body as a universal life element and have been clarified to act as an important electron transfer conductor that supports energy metabolism, protein quality control, and signal transduction. Supersulfides are thought to sense oxygen and reactive oxygen species and are responsible for their biological activities. They also play a key role in the creation of physiological functions of major biomolecules such as nucleic acids and proteins, and support a wide range of biological phenomena. We will introduce cutting-edge technologies on quantitative sulfur omics, sulfur imaging, and chemical modulators necessary for elucidating the functional interactions between supersulfides and various related molecules and biological systems. We will discuss a multidisciplinary approach to building a consortium on global standards for sulfur metabolic flux. Furthermore, we will create innovative biology utilizing these technologies for measuring supersulfides, and renew the biological concept of physiological and pathological functions useful for human health care.

Innovative sulfur biology and its translational application emerging from supersulfides

The 143rd Annual Meeting of the Pharmaceutical Society of Japan (Sapporo)

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[S09-01]Sulfur metabolism regulation and cytoprotection by NRF2

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