The 143rd Annual Meeting of the Pharmaceutical Society of Japan (Sapporo)
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Session Details

Poster Presentation(A) Pharmaceutical Chemistry

[27P1-pm2]Chemical biology/Drug design/Natural medicines and biological products/Pharmacologically active compounds/Structure-activity relationship/Others

Mon. Mar 27, 2023 3:40 PM - 5:20 PM JST
Mon. Mar 27, 2023 6:40 AM - 8:20 AM UTC
[Room P1] Gymnasium 1F

[27P1-pm2-076S]Evaluation of CuAAC reaction with alkyne-incorporated peptides

○Azusa Sano1, Keito Ogawa1, Yuki Shinozaki1, Hiroki Tanimoto1, Takenori Tomohiro1 (1. Fac. Pharm. Sci., Univ. of Toyama)

[27P1-pm2-077]Evaluation of sulfonamide-substituted 4-oxoDHA as a PPARγ ligand

○Nami Ohashi1, Arimi Miura1, Hiroaki Ishida1, Toshimasa Itoh1 (1. Showa Pharm. Univ.)

[27P1-pm2-078S]Dual covalent strategy for development of irreversible GPX4 inhibitors

○Takuto Nagao1, Naoya Shindo1, Akio Ojida1 (1. Grad. Sch. Pharm. Sci., Kyushu Univ.)

[27P1-pm2-079S]Targeted degradation of proteins in mitochondrial matrix by harnessing ClpP

○Wakana Yamada1, Shinichi Sato1,2, Minoru Ishikawa1, Shusuke Tomoshige1 (1. Grad. Sch. Life Sci., Tohoku Univ., 2. FRIS., Tohoku Univ.)

[27P1-pm2-080S]Cysteine selective peptide bond cleavage using cyanopyridine derivatives

○Tetsuya Yano1, Takahiro Yamada1, Hiroaki Ishida1, Nami Ohashi1, Toshimasa Itoh1 (1. Showa Pharm. Univ.)

[27P1-pm2-082]Some metal complexes can activate VDR

Mami Yoshizawa1, Eri Shimizu1, Nami Ohashi1, Hiroaki Ishida1, Takahiro Yamada1, ○Toshimasa Itoh1 (1. Showa Pharm. Univ.)

[27P1-pm2-083S]Development of Iron Chelators for Regulation of Intracellular Iron Dynamics

○Yuna Yamada1, Yuta Fujikawa1, Hijiri Oshio2, Shiiba Isshin2, Yanagi Shigeru2, Hideshi Inoue1 (1. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci., 2. Fac. Sci., Gakushuin Univ.)

[27P1-pm2-084]Development of new photoactivatable peroxide caged compound targeting mitochondria

○Mieko Tsuji1, Tasuku Hirayama1, Hideko Nagasawa1 (1. Gifu Pharm Univ.)

[27P1-pm2-085S]Excited-state modulation of photosensitizer by COT

○Ryo Kawana1, Tasuku Ueno1, Yasuteru Urano1,2 (1. Grad. Sch. Pharm. Sci., Univ. of Tokyo, 2. Grad. Sch. Med., Univ. of Tokyo)

[27P1-pm2-086]Effect of 5’-Modification on the Asymmetry Recognition of siRNA and the Elimination of Off-Target Effect

○Masayuki Fujii1, Yojiro Kotake1, Yasuo Shiohama2 (1. Sci Tech., Kindai University, 2. Sch. Med., University of Yamaguchi)

[27P1-pm2-087]Solid-phase synthesis of unnatural polyamines and its effect on DNA thermal stability

○Naoki Umezawa1, Masashi Yamaguchi1, Yosuke Hisamatsu1, Tsunehiko Higuchi1 (1. Grad. Sch. Pharm. Sci., Nagoya City Univ.)

[27P1-pm2-088]Synthesis of Planar Inclusion Compounds that Recognize Neurotransmitters

○Kaori Ota1, Makoto Furutachi1 (1. Fukuoka University)

[27P1-pm2-089S]Studies on improvement of synthetic pathway and yield of a ferulic acid derivative FAD041

○Koichi Shikama1, Kenta Ogawa1, Jun Takayama1, Meiyan Xuan1, Hirokazu Matsuzaki1, Bo Yuan1, Mari Okazaki1, Takeshi Sakamoto1 (1. Fac. Pharm. Sci., Josai Univ.)

[27P1-pm2-090S]Synthetic studies of new derivatives with antioxidant and antinecroptosis activities.

○Kazuma Komai1, Koichi Shikama1, Kenta Ogawa1, Jun Takayama1, Meiyan Xuan1, Hirokazu Matsuzaki1, Bo Yuan1, Mari Okazaki1, Takeshi Sakamoto1 (1. Fac. Pharm. Sci., Josai Univ.)

[27P1-pm2-091S]Investigation of synthesis of ferulic acid derivatives with 1,2,4-oxadiazole ring

○Takuma Okusawa1, Koichi Shikama1, Jun Takayama1, Meiyan Xuan1, Hirokazu Matsuzaki1, Bo Yuan1, Mari Okazaki1, Takeshi Sakamoto1 (1. Fac. Pharm. Sci., Josai Univ.)

[27P1-pm2-092]Synthetic studies of modulators for short-chain fatty acid receptor 3 as new potential therapeutic targets

○Ken-ichi Iwamoto1, Ryodai Enomoto1, Atsukazu Kuwahara2, Yasutada Akiba3, Jonathan D. Kaunitz3, Kei Manabe1 (1. University of Shizuoka, 2. Yamagata University, 3. University of California, Los Angels)

[27P1-pm2-093S]Design, synthesis and biological activity of novel 3-(4-butoxyphenyl)propan-2-amine derivatives as ceramide equivalents

○Takuto Ichikawa1, Kazuya Nakayama1, Yuya Moriguchi1, Risa Togo1, Kentaro Kawai1, Yukiko Karuo1, Atsushi Tarui1, Kazuyuki Sato1, Kazuyuki Kitatani1, Masaaki Omote1 (1. Dep. Pharm. Sci., Setsunan Univ.)

[27P1-pm2-094S]Design, Synthesis and Biological Evaluation of Multiple Boron Carriers Equipped with Macrocyclic Polyamines for Boron Neutron Capture Therapy

○Kenta Kawamoto1, Hiroki Ueda2, Minoru Suzuki2, Yoshinori Sakurai2, Tomohiro Tanaka3, Shin Aoki1,4 (1. Faculty of Pharmaceutical Sciences, Tokyo University of Science , 2. Institute for Integrated Radiation and Nuclear Science, Kyoto University , 3. Okayama univ., 4. Research Institute for Science and Technology, Tokyo University of Science)

[27P1-pm2-095]Synthesis of the vitamin D receptor ligand containing three-membered heterocycles

○Hiroaki Ishida1, Honami Ozawa1, Toshimasa Itoh1 (1. Showa Pharm. Univ.)

[27P1-pm2-096]Construction of two-hybrid assay system for searching for novel FXR ligands

○Yusuke Iguchi1, Misato Azumaya1, Yuka Kakinami1, Yukiko Yamashita1, Mizuho Une1 (1. Fac. Pharm. Sci., Hiroshima International Univ.)

[27P1-pm2-097S]Development of a novel boron carrier for BNCT exploiting a tumor-specific amino acid transport system

○Akiho Niitsu1, Ryota Yamamoto1, Yu Sanada2, Tsubasa Watanabe2, Shinichiro Masunaga2,3, Mieko Tsuji1, Tasuku Hirayama1, Hideko Nagasawa1 (1. Gifu Pharm. Univ., 2. KURNS, 3. Hanwa Daini Senboku Hospital)

[27P1-pm2-098]Design, synthesis and biological evaluation of novel inhibitors against cyclin-dependent kinase 8

○Jui-Yi Hsu1, Chia-Ron Yang2, Wei-Jan Huang*3, Kai-Cheng Hsu*4 (1. Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan, 2. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, 3. School of Pharmacy, Taipei Medical University, Taipei, Taiwan, 4. Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan)

[27P1-pm2-099S]Discovery and biological evaluation of 2-aminophenyl chromone derivatives as anti-proliferative agents against multidrug resistance cancers

○Yi-Han Chang1, I-Ting Wu2, Chin-Chuan Hung2, Hsin-Yi Hung1 (1. Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University, Tainan, Taiwan, 2. Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan)

[27P1-pm2-100]Screening of antibacterial plant extracts using AI (3rd report): Anti-staphylococcal activity of Cinnamomum sielboldii essential oil

Hiroaki Yabuuchi2, ○Ryuji Kasamatsu1, Kazuhito Hayashi1, Makiko Fujiwara1, Takeshi Ogusu1, Megumi Mori1, Kazuyuki Miyai1 (1. WINTEC, 2. Wakayama Prefectural Higashimuro Promotions Bureau)

[27P1-pm2-101]The efficacy of new cultivars of Paeonia lactiflora flower extract ‘YUMESAIKA’

○Kensuke Yotsumoto1, Katura Sano1, Ayano Kinjo1, Hiroyuki Fuchino2, Motoko Igarashi2, Atsuyuki Hishida2,3 (1. ALBION CO., LTD., 2. National Institutes of Biomedical Innovation, Health and Nutrition, 3. Tokyo University of Agriculture)

[27P1-pm2-102S]Evaluation of anti-inflammatory components from Tabebuia avellanedae

○Hikari Imazu1, Mitsuaki Yamashita1, Youchi Fukuda1, Akira Iida1 (1. Sch. Agri., Kindai Univ.)

[27P1-pm2-103S]Synthesis and evaluation of biosynthetic intermediates of furanonaphthoquinone isolated from Tabebuia avellanedae

○Minami Koya1, Mitsuaki Yamashita1, Iida Akira1 (1. Sch. Agri., Kindai Univ.)

[27P1-pm2-104S]STAT3 inhibitory activity of fluorine-containing naphthoquinone derivatives

○Arisa Tsukamoto1, Mitsuaki Yamashita1, Akira Iida1 (1. Grad. Sch. Agric., Kindai Univ.)

[27P1-pm2-105]Study on the search of anti-cancer drug resistance-overcoming compound from soil fungus

○Tadahiro Etoh1, Yuki Sato1, Ryoto Meguro1, Fuma Hiki1, Miyu Toda1, Sakurako Tanaka1, Hiromi Torii1, Kurumi Aayabe1, Yong pil Kim1,2 (1. Fac. Pharm., Iryo Sosei Univ., 2. Grad. Sch. Life Sci. Technol., Iryo Sosei Univ.)

[27P1-pm2-106]Evaluation of anticancer activity of bronanserin major metabolites against glioblastoma.

○Kenya Okamoto1, Natsumi Tsuchiya1, Azuki Moriyama1, Shuhei Nakao1, Miyuki Mabuchi1, Tadashi Shimizu1 (1. Sch.Pharm.Hyogo Medical Univ.)

[27P1-pm2-107]Modulation effects of Chennat-type 1,4-dihydropyridinne compounds to histone deacetylase.

○Nagisa Sasaki1, Yukina Shinozaki1, Yosinori Okuno1, Shigeki Isomura1, Miho Sawada2, Yukihiro Itoh2, Takayoshi Suzuki2, Yasuo Sato1 (1. Yokohama University of Pharmacy, 2. ISIR Osaka University)

[27P1-pm2-108S]A study on efflux pump inhibitors of bacterial MATE-type transporters responsible for multidrug resistance

○Susumu Shinya1, Kentaro Kawai1, Naoki Kobayashi2, Yukiko Karuo1, Atsushi Tarui1, Kazuyuki Sato1, Masato Otsuka1, Masaaki Omote1 (1. Fac. Pharm. Sci., Setsunan Univ., 2. Dep. Agric., Setsunan Univ.)

[27P1-pm2-109S]Synthesis of Thiophene Carboxamides with Alkyl Chain Comprising Ethylene Glycol Units, and Their Growth Inhibitory Activity against Glioblastoma Stem Cells

○Tatsuya Takahashi1, Kaito Ohta1, Yuri Tatsuishi 1, Shota Ando1, Chiami Moyama1, Hiromi Ii 1, Susumu Nakata1, Hiroki Iwaski 1, Masayuki Yamashita1, Hisanori Nambu1, Naoto Kojima1 (1. Kyoto Pharm Univ)

[27P1-pm2-110S]Design and synthesis of novel orexin 1 receptor selective antagonist with spiroindanopiperidine skeleton

○Takumi Saito1, Sayaka Ohrui1, Minami Takanashi1, Shunsuke Kasuya1, Masanori Tayu1, Yukiko Ishikawa2, Yoko Irukayama2, Masashi Yanagisawa2, Nozomi Saito1 (1. Meiji Pharm. Univ., 2. WPI-IIIS, Univ. Tsukuba)

[27P1-pm2-111]Novel Aprosamine Derivatives Active Against Multidrug-resistant Gram-negative Bacteria

○Yasunari Otsuka1, Eijiro Umemura1, Yukimi Takamiya1, Teruhisa Ishibashi1, Chigusa Hayashi1, Keiko Yamada2, Masayuki Igarashi1, Masakatsu Shibasaki1, Yoshiaki Takahashi1 (1. IMC, 2. Meiji Seika Pharma)

[27P1-pm2-112]Structure and solubility, passive diffusivity, cell membrane permeability, and P-gp substrate properties of optically active cyclopropane-containing cyclic peptides.

○Hiroyuki Miyachi1, Kayoko Kanamitsu1, Mayumi Ishii1, Eri Watanabe1, Yukina Sato2, Takayuki Osada2, Yuuki Yamazaki2, Hitoshi Kashiwagi2, Mitsuru Sugawara2, Satoshi Shuto2, Yasuteru Shigeta3, Mizuki Watanabe2, Katsumi Maenaka2 (1. DDI, Grad. Sch. Pharm. Sci., TOKYO university, 2. Grad. Sch. Pharm. Sci., HOKKAIDO university, 3. Cent. comp. Sci., TSUKUBA Univ)

[27P1-pm2-113S]Structure-Activity Relationship Study of Coibamide A Derivatives: Transformation of N-Terminal Tail Region

○Rina Tsujioka1, Rikito Suzuki1,2, Daphne R. Mattos3, Kazuya Kobayashi1, Jane E. Ishmael3, Kerry L. McPhail3, Shinya Oishi1,2 (1. Kyoto Pharm. Univ., 2. Grad. Sch. Pharm. Sci., Kyoto Univ., 3. Oregon State Univ.)

[27P1-pm2-114]Synthesis of internally quenched fluorescent peptide substrate containing α-synuclein partial sequence and screening of human antibody light chains

○Taguchi Hiroaki1, Ryouta Isshiki1, Arisa Matsuo1, Satoshi Nakagawa1, Emi Hifumi2, Taizou Uda3 (1. Grad. Sch. Pharm. Sci. Suzuka Univ. Med. Sci., 2. Res. Manag., Ohita Univ., 3. Ins. Sys., Inf. Tech. and Nanotech.)

[27P1-pm2-115]Regulatory science research on continuous flow synthesis of active pharmaceutical ingredients

○Takuji Shoda1, Hisayo Aoki1, Yosuke Demizu1, Tomoaki Sakamoto1 (1. Natl. Inst. Health Sci.)
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