The 143rd Annual Meeting of the Pharmaceutical Society of Japan (Sapporo)
Advanced Search

Session Details

Poster Presentation(A) Pharmaceutical Chemistry

[28P1-am1]Chemical biology/Drug design/Synthetic compounds in drug discovery/Natural medicines and biological products/Structure-activity relationship/Others

Tue. Mar 28, 2023 9:00 AM - 10:40 AM JST
Tue. Mar 28, 2023 12:00 AM - 1:40 AM UTC
[Room P1] Gymnasium 1F

[28P1-am1-091S]Intracellular delivery of oligonucleotides using amphipathic stapled peptides.

○Motoharu Hirano1,2, Hidetomo Yokoo3, Makoto Oba3, Takashi Misawa2, Yosuke Demizu1,2 (1. Grad. Sch. Med, Life. Sci., Yokohama City Univ., 2. NIHS, 3. Kyoto Pref. Univ. Med.)

[28P1-am1-092S]Effects of dose-dependency and age-related alteration of myostatin inhibitory peptide on muscle hypertrophy in mice

○Minori Nishikawa1, Risa Teranishi1, Tetsuya Wada1, Katsuya Morito1, Kazuki Nagasawa1, Kentaro Takayama1 (1. Kyoto Pharm. Univ.)

[28P1-am1-093S]Effect of MID-35, myostatin inhibitory peptide, on skeletal muscle mass in high-fat diet-induced obese mice

○Risa Teranishi1, Minori Nishikawa1, Katsuya Morito1, Kazuki Nagasawa1, Kentaro Takayama1 (1. Kyoto Pharm.Univ)

[28P1-am1-094S]Discovery of new degron sequences for PROTAC design

○Reina Takano1, Takashi Kurohara2, Nobumichi Ohoka2, Kenji Ohgane3, Takao Inoue2, Yosuke Demizu1,2 (1. Sci., Yokohama City Univ., 2. NIHS, 3. Sci., Ochanomizu Univ.)

[28P1-am1-095]Development of intracellular delivery carriers based on cell-penetrating peptides for siRNA and mRNA

Hidetomo Yokoo1, Satoshi Uchida1, ○Makoto Oba1 (1. Grad. Sch. Med. Sci., Kyoto Pref. Univ. Med.)

[28P1-am1-096S]Development of a highly efficient photocontrollable NO releaser containing a photosensitizing dye as an antenna

○Daisuke Saitoh1, Naoya Ieda1, Kyoya Oyama2, Yuji Hotta1, Mitsuyasu Kawaguchi1, Kazunori Kimura1, Hidehiko Nakagawa1 (1. Grad. Sch. of Pharm. Sci., Nagoya City Univ., 2. Fac. of Pharm. Sci., Nagoya City Univ.)

[28P1-am1-097]Synthesis of dicationic cytosine derivative for strand invasion with peptide nucleic acids

○Shun-suke Moriya1, Misaki Yonezu1, Yuzu Kondo1, Yosuke Demizu2, Masaaki Kurihara3, Atsushi Kittaka1, Toru Sugiyama1 (1. Fac. of Pharma-Sciences, Teikyo Univ., 2. Div. of Org. Chem., Nat. Inst. of Health Sci., 3. Dept. of Pharm. Sci., Shonan Univ. of Med. Sci.)

[28P1-am1-098]Study for structural optimization of fluorescent sensors for N1-methyladenosine

Yuki Oka1, Seira Kitagawa1, Yoshino Takenobu1, Aika Taka1, Daisuke Yasuda1, Takuya Kamikawa2, Hiroyuki Kagechika2, Tomoyuki Ohe3, ○Tomoya Hirano1 (1. Fac. Pharm., Osaka Med. Pharm. Univ., 2. Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ., 3. Fac. Pharm., Keio Univ.)

[28P1-am1-099S]A bio-orthogonal, engineered probe-enzyme pair for sensitive fluorescence imaging of cancer cells with low background

○Ziyi Wang1, Ryosuke Kojima1, Kyohhei Fujita1, Yasuteru Urano1,2 (1. Grad. Sch. Med., The University of Tokyo, 2. Grad. Sch. Pharm. Sci., The University of Tokyo)

[28P1-am1-100S]Identification of the target proteins for photoactivated killing of HTLV-1 infected cells

○Yoshikazu Fuse1, Eita Sasaki1,2, Tadashi Hirotani2, Sota Yamada1,2, Hideki Nakasone3, Kenjiro Hanaoka1,2 (1. Fac. Pharm. Keio Univ., 2. Grad. Sch. Pharm. Sci. Keio Univ., 3. Sch. Med. Jichi Med. Univ.)

[28P1-am1-101S]Development of fluorescent probes for sensing enzymatic activities based on the twisted intramolecular charge transfer (TICT) mechanism

○Mizuki Sugimoto1, Eita Sasaki1,2, Hisashi Ohno2, Kenjiro Hanaoka1,2 (1. Fac.Pharm.Keio Univ., 2. Grad. Sch. Pharm. Sci. Keio Univ.)

[28P1-am1-102]Development of protein shells to encapsulate specific target proteins

Ayaka Takeda1, ○Eita Sasaki1,2, Sota Yamada1,2, Kenjiro Hanaoka1,2 (1. Fac. Pharm. Keio Univ., 2. Grad. Sch. Pharm. Sci. Keio Univ.)

[28P1-am1-103]Development of novel labeling methods to identify isomerized amino acid residues among the protein.

○morimoto shota1, sugino nao1, yamaguchi ami1, sadakane yutaka1 (1. Pharm. suzuka Univ.)

[28P1-am1-104]Molecular design methodology of cyclic peptide inhibitors with cell membrane permeability, and its application to the development of MDMX inhibitors

○Kyosuke Tsumura1, Takashi Tamura2, Mai Mizuno2, Koo Suzuki1, Noriyuki Ohashi1, Masahiro Kochi1, Kenta Miyahara1, Ichihiko Hashimoto1 (1. Analysis Technology Center, FUJIFILM Corporation, 2. Synthetic Organic Chemistry Laboratories, FUJIFILM Corporation)

[28P1-am1-105S]Substrate reactivity relationships of anti-SARS-CoV-2 compound N3 and development of PROTAC thereof

Mori Hosaka2, Daichi Chida2, ○Ryo Watanabe1, Hiroyuki Yamakoshi1,2, Takashi Toyama1,2, Yoshiro Saito1,2, Yoshiharu Iwabuchi1,2 (1. Fac. Pharm. Sci., Tohoku Univ., 2. Grad. Sch. Pharm. Sci., Tohoku Univ.)

[28P1-am1-106]Effect of alkyl chain length of 5-C-alkyl-L-ido-DNJ, the pharmacological chaperones for lysosomal acid α-glucosidase, on activities and binding orientations

○Izumi Nakagome1, Atsushi Kato2, Kosuke Yoshimura2, Uta Kanekiyo2, Noriyuki Yamaotsu1, Nobutada Tanaka1 (1. Kitasato Univ., Sch. Pharm., 2. Department of Hospital Pharmacy, University of Toyama)

[28P1-am1-107S]Strategy for designing a 1-deoxynojirimycin-based pharmacological chaperone for Pompe disease

○Kosuke Yoshimura1, Izumi Nakagome2, Uta Kanekiyo1, Kenta Shinzawa1, Tomoki Yoshida2, Nobutada Tanaka2, Atsushi Kato1 (1. Department of Hospital Pharmacy, University of Toyama, 2. School of Pharmaceutical Sciences, Kitasato University)

[28P1-am1-108S]Structure-activity relationships of C-6 fluorinated casuarine derivatives against various glycosidase inhibitions

○yuna shimadate1, maki kise1, kennta shinzawa1, atsushi kato1 (1. Department of Hospital Pharmacy, University of Toyama)

[28P1-am1-109]Intracellular Nrf2 activation effect of naphthalene-2-acetamide derivatives

○Daisuke Yasuda1, Daiki Katagishi2, Tomoyuki Ohe2, Tomoya Hirano1 (1. Fac. Pharm., Osaka Med. and Pharm. Univ., 2. Keio Univ.)

[28P1-am1-110]Efficient synthesis of carbasugar SGLT2 inhibitors using azide–alkyne click chemistry

○Yoshiaki Kitamura1,2,3,4, Keitaro Iritani2, Erina Oba2, Chiori Iwai2, Nanako Nagaya1, Reo Namura1 (1. Fac. Eng., Gifu Univ., 2. Grad. Sch. Nat. Sci. Tech., Gifu Univ., 3. United Grad. Sch. Drug Discov. Med. Info. Sci., Gifu Univ., 4. Ctr. One Med. Innov. Transl. Res., Gifu Univ.)

[28P1-am1-111S]Synthesis of 4'-fluoro-carbocyclic uridine derivatives targeting SARS-CoV-2 RNA polymerase

○Kaho Ishijima1, Seiko Miyazawa1, Shinichiro Hattori2, Makoto Roppongi3, Hiroaki Mitsuya2, Kiju Konno1 (1. International Univ. of Health and Welfare, 2. Research Institute National Center for Global health and Medicine, 3. Utsunomiya Univ.)

[28P1-am1-112S]Synthesis of 4'-fluoro-carbocyclic adenosine targeting SARS-CoV-2 RNA polymerase

○Ayami Takayama1, Shinichiro Hattori2, Makoto Roppongi3, Hiroaki Mitsuya2, Kiju Konno1 (1. International Univ. of Health and Welfare, 2. Research Institute National Center for Global health and Medicine, 3. Utsunomiya Univ.)

[28P1-am1-113S]Development of a mirror-image VHH antibody for a novel non-immunogenic drug scaffold

○Keisuke Aoki1,2, Motohiro Nonaka3, Sakiho Oda3, Katsuaki Higashi3, Asako Manabe3, Hiroyuki Kimura2, Shinsuke Inuki1, Hiroaki Ohno1, Shinya Oishi1,2 (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. Kyoto Pharmaceutical Univ., 3. Grad. Sch. Med., Kyoto Univ.)

[28P1-am1-114]Suppression of dextran sulfate sodium-induced colitis in mice treated with falcarindiol

○Tomokazu Ohnuma1, Rika Hoashi1, Takahito Nishiyama1, Kenichiro Ogura1, Akira Hiratsuka1 (1. School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)

[28P1-am1-115S]Synthetic studies of Andrastine analogues for the development of novel FTase inhibitors

○Fumino Kitamura1, Ayano Kosaka1, Masaru Tanioka1, Yuji Matsuya1 (1. Faculty of Pharm. Sci., University of Toyama)

[28P1-am1-116]Inhibitory effects of sinomenine derivatives against acute nociceptive response induced by formalin on mice

○Hiroki Kataoka1, Soh Katsuyama1, Yukino Ogasawara1, Ren Aikawa1, Natsumi Tanaka1, Naoko Okada1, Toshiaki Saitoh1, Fumihide Takano1, Chikai Sakurada1 (1. Nihon Pharmaceutical University)

[28P1-am1-117S]Concise total synthesis of makaluvamine J and analogs

○Yo Kiichi1, Koya Ishino1, Koshiro Fukuoka1, Sota Takata1, Satsuki Takaoka1, Naoyuki Kotoku1 (1. Coll. Pharm. Sci., Ritsumeikan Univ.)

[28P1-am1-118S]Synthesis and structure-activity relationship of novel analogs of arenastatin A

○Yurina Mihara1, Kohei Hatta1, Haruki Kadoya1, Soki Kakihana1, Naoyuki Kotoku1 (1. Coll. Pharm. Sci., Ritsumeikan Univ.)

[28P1-am1-119S]Structure-activity relationship study on the P4 structure of a macrocyclic BACE1 inhibitor

○Momoka Kawakita1, Takuya Otani2, Yasunao Hattori1, Shinya Oishi1, Kazuya Kobayashi1 (1. Kyoto Pharm. Univ., 2. Kansai Med. Univ.)

[28P1-am1-120]Discovery and SARs of novel IDO1/TDO dual inhibitors

○Naohisa Ogo1, Kazuaki Tajima1, Yurika Kawai1, Katsumi Ohta1, Hisashi Murakami1, Osamu Takikawa2, Akira Asai1 (1. Grad. Div. Pharm. Sci., Univ. of Shizuoka, 2. National Center for Geriatrics and Gerontology)

[28P1-am1-121S]Study on process of molecular descriptor generation by Transformer

○Yasuhiro Yoshikai1, Tadahaya Mizuno1, Shumpei Nemoto1, Hiroyuki Kusuhara1 (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo)

[28P1-am1-122S]Structure-based strategy for drug discovery in Type 2 Diabetes

○Chinami Imanishi1, Maki Sadatomo1, Yukiko Yamashita1, Keisuke Oda1, Yusuke Iguchi1, Akira Matsuda1, Yorimitsu Kodama1, Mizuho Une1 (1. Fac. Pharm. Sci., Hiroshima International Univ.)

[28P1-am1-123]Development of arylidene thiazolidinedione derivatives as anti-austerity agents against cancer cells

○Akira Takagi1, Satoshi Kitanishi1, Kentaro Oh-hashi2, Kensuke Okuda1 (1. Kobe Pharm. Univ., 2. Fac. Eng., Gifu Univ.)

[28P1-am1-124S]Structure activity relationship studies of purine derivatives with CK2 inhibitory activity
–Design of CK2 inhibitors keeping crystal water in the binding pocket–

○Shiori Nakatani1, Eri Nakagawa1, Kenji Yoshioka1, Keiji Nishiwaki1, Shinya Nakamura1, Masato Tsuyuguchi2,3, Takayoshi Kinoshita2, Isao Nakanishi1 (1. Fac. Pharm., Kindai Univ., 2. Grad. Sch. Sci., Osaka Met. Univ., 3. KEK)

[28P1-am1-125]Synthesis of novel triaryl derivatives with read-through-inducing activity

○Shota Kawai1, Shunsuke Takashima1, Masafumi Ando1, Sayaka Shintaku1, Kazuya Otake1, Megumi Yamamoto1, Yoshimichi Shoji1, Tatsuya Kitao1, Hiroaki Shirahase1 (1. Kyoto Pharmaceutical Industries, Ltd.)

[28P1-am1-126]Synthesis and structure-activity relationship of novel benzofuran derivatives with osteoblast differentiation-promoting activity

○Masafumi Ando1, Shota Kawai1, Ko Morishita1, Shunsuke Takashima1, Kazuya Otake1, Megumi Yamamoto1, Yoshimichi Shoji1, Tatsuya Kitao1, Hiroaki Shirahase1 (1. Kyoto Pharmaceutical Industries, Ltd.)

[28P1-am1-128S]Development of fluorescent labeling reagents for glycoproteins

○Miyu Ito1, Yurina Sekine1, Takuji Shoda2, Noritaka Hashii2, Akira Harazono2, Akiko Ishii-Watabe2, Hideshi Inoue1, Yosuke Demizu2,3 (1. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci., 2. NIHS, 3. Grad. Sch. Med. Life Sci., Yokohama City Univ.)

[28P1-am1-129]Effect of Lys replacement with Arg in MAP(Aib) on siRNA delivery into cells

○Shun-ichi Wada1, Takumi Shimoda1, Junsuke Hayashi1, Hidehito Urata1 (1. Fac. Pharm, Osaka Med. Pharm. Univ.)
Back to Category List