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Synthetic studies of sialic acid-containing glycans for middle molecule drug discovery

In recent years, mid-size drugs such as peptides and nucleic acids have attracted attention as a new modality that combines the advantages of both small molecule drugs and biopharmaceuticals. Mid-size drugs have the characteristics of being able to target intracellular targets, have high target specificity, and can be chemically synthesized, and is expected to be a next-generation drug that will play a role in expanding drug discovery targets. <br />  With the aim of creating mid-size drugs, a variety of research is underway, focusing on a wide range of molecular types, including peptides, nucleic acids, sugar chains, and artificial chimeric molecules. To efficiently synthesize and highly functionalize these molecules, next-generation molecular and analytical technologies suitable for molecular species, new functionalization concepts and fusion research between molecular types are required. In this symposium, "Frontiers of mid-size drug discovery research—next generation molecular technology that contributes to mid-size drug discovery—", five speakers with diverse molecular technologies contributing to mid-size drug discovery will give lectures on some of the latest research.

Frontiers of mid-size drug discovery research —next generation molecular technology that contributes to mid-size drug discovery—

The 144th Annual Meeting of the Pharmaceutical Society of Japan (Yokohama)

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[S19-2]Synthetic studies of sialic acid-containing glycans for middle molecule drug discovery

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