The 144th Annual Meeting of the Pharmaceutical Society of Japan (Yokohama)
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Session Details

Poster Presentation(A) Pharmaceutical Chemistry

Chemical biology

Fri. Mar 29, 2024 8:30 AM - 12:00 PM JST
Fri. Mar 29, 2024 11:30 PM - 3:00 AM UTC
[Poster 3] Exhibition Hall AB (1F)

[29P-am091S]Development of PROTAC with photodegradable linkers

○Hanqiao Xu1,2, Hidetomo Yokoo2, Nobumichi Ohoka2, Takao Inoue2, Yosuke Demizu1,2 (1. Grad. Sch. Med. Life Sci., Yokohama City Univ., 2. NIHS)

[29P-am092S]Screening of G-quadruplex (G4) structure-specific peptide probes

○Naka Ida1, Yoshimasa Kawaguchi1, Shiroh Futaki1, Miki Imanishi1 (1. Institute for Chemical Research, Kyoto Univ.)

[29P-am093]Cationic cytosine analogue of peptide nucleic acid monomer for enhanced DNA hybridization stability

○Shun-suke Moriya1, Mana Oishi1, Yosuke Demizu2, Masaaki Kurihara3, Atsushi Kittaka1, Toru Sugiyama1 (1. Fac. of Pharm-Sciences, Teikyo Univ., 2. Nat. Inst. of Health Sci., 3. Dept. of Pharm. Sci., Shonan Univ. of Med. Sci.)

[29P-am094S]Development of novel selective inhibitors for a reactive sulfur species-producing enzyme, cystathionine β-synthase (CBS)

○Ko Hirabayashi1, Eita Sasaki1,2, Honami Echizen3, Hisashi Ohno2, Kenjiro Hanaoka1,2 (1. Fac. Pharm. Keio Univ., 2. Grad. Sch. Pharm. Sci. Keio Univ., 3. Grad. Sch. Pharm. Sci., The Univ. of Tokyo)

[29P-am095S]Efficient intracellular delivery of PROTAC using cell-penetrating peptides

○Maho Miyamoto1,2, Hidetomo Yokoo2, Yosuke Demizu1,2 (1. Sci., Yokohama City Univ., 2. NIHS)

[29P-am096S]Studies on structural properties of peptoid nucleic acids

○Sawa Takeda1,2, Hidetomo Yokoo2, Yousuke Demizu1,2 (1. Grad. Sch. Med., Dent. and Pharm. Sci., 2. NIHS)

[29P-am097S]Reducing environment-responsive peptides that inhibit intracellular p53/MDM2 protein-protein interactions

○Kazuma Arakawa1, Maiko Kato1, Yasumichi Inoue1, Hidetoshi Hayashi1, Yosuke Hisamatsu1, Naoki Umezawa1 (1. Grad. Sch. Pharm. Sci., Nagoya city University)

[29P-am098]Development of delivery carriers using hydrophobic cell-penetrating stapled peptides

○Hidetomo Yokoo1, Tsuchiya Keisuke1,2,3, Horikoshi Kanako1,4, Fujita Minami1,4, Hirano Motoharu1,4, Miyamoto Maho1,4, Shu Dozhou1,4, Demizu Yosuke1,3,4,5 (1. NIHS, 2. Fac. Pharm. Sci., Sanyo-Onoda City Univ., 3. Grad. Sch. Pharm., Showa Univ., 4. Grad. Sch. Med, Life. Sci., Yokohama City Univ., 5. Grad. Sch. Med. Dent. Pharm. Sci., Okayama Univ.)

[29P-am099S]Synthesis and structure-activity relationship study of 3-aminosterol derivatives as STING modulators

○Rio Tsuyuki1, Elena Nakasato3, Kanoko Takahashi2, Yoshihiko Kuchitsu2, Minoru Ishikawa2, Kojiro Mukai2, Tomohiko Taguchi2, Kenji Ohgane3 (1. Dept of Chem., Ochanomizu Univ., 2. Grad. Sch. Life Sci., Tohoku Univ., 3. Grad. Sch. Sci., Ochanomizu Univ.)

[29P-am100S]Development of senescent cell-selective removal technology using near-infrared light

○Minori Sano1, Eita Sasaki1,2, Kento Takaya3, Kazuo Kishi3, Kenjiro Hanaoka1,2 (1. Fac. Pharm. Keio Univ., 2. Grad. Sch. Pharm. Sci. Keio Univ., 3. Sch. Med. Keio Univ.)

[29P-am101]Activation of FMR1 gene transcription by small molecule accumulation on CGG repeat sequence

○Hirotaka Murase1, Kosuke Kawakubo2, Norifumi Shioda2, Shigeki Sasaki3 (1. Faculty of Pharm. Sci., Sojo Univ., 2. IMEG, Kumamoto Univ., 3. Grad. School of Pharm. Sci., Nagasaki Int. Univ.)

[29P-am102]Development a proteolysis targeting chimera using a E3 ligase, CHIP

○Tokiha Masuda-Ozawa1, Shusuke Tomoshige1, Shinich Sato1,2, Fumiaki Ohtake3, Minoru Ishikawa1 (1. Grad. Sch. Life Sci., Tohoku Univ., 2. FRIS, Tohoku Univ., 3. Hoshi Univ.)

[29P-am103S]Synthesis and mechanism elucidation of tetracyclic furoindoline as a Notch inhibitor

○Haruki Matsuda1, Takeshi Yamada2, Midori A. Arai1 (1. Fac. Sci. Tec., Keio Univ., 2. Kobe Pharm. Univ.)

[29P-am104S]Development of chemical probes for fluorescence detection and labeling of hydropersulfide

○Keisho Hirao1, Haruki Yamaguchi1, Hisayuki Wakamori1, Mitsuyasu Kawaguchi1, Naoya Ieda2, Hidehiko Nakagawa1 (1. Grad. Sch. Pharm. Sci., Nagoya City Univ., 2. Grad. Sch. Pharm. Sci., Hokkaido Univ.)

[29P-am105S]Screening and analysis of chemical library for the arylazopyrazole type of photopharmacological ligands prepared by the cyclization reaction

○Honoka Ogawa1, Shusuke Yamaoka1, Kazuya Matsuo1, Tomonori Waku1, Akio Kobori1 (1. Kyoto Institute of Technology)

[29P-am106S]Development of novel covalent inhibitors for glutaminase 1

○Xiwen Xiao1, Saki Inoue1, Shohei Uchinomiya1, Akio Ojida1 (1. Grad. Sch. Pharm. Sci.,Kyushu Univ.)

[29P-am107S]Development of fluorescence probes for sensing protein synthesis in mitochondria

○Shun Sumitani1, Eita Sasaki1,2, Hisashi Ohno2, Kenjiro Hanaoka1,2 (1. Fac. Pharm., Keio Univ., 2. Grad. Sch. of Pharm. Sci., Keio Univ.)

[29P-am108S]Development of a new HGSNAT activity assay based on azamornadine formation reaction

○Haruka Matsui1, Kenji Ohgane1 (1. Dept of Chem., Ochanomizu Univ.)

[29P-am109S]Fluorometric analysis on the carnosine tagged with a fluorescent kynurenate derivative.

○Hiroshi Sugasawa1, Tatsuya Sakamoto1, Mayu Onozato1, Takeshi Fukushima1 (1. Faculty of Pharm. Sci., Toho Univ.)

[29P-am110S]A Study on MATE inhibitors of bacteria to get initial SAR

○Kazuki Alba Pastor1, Susumu Shinya1, Kentaro Kawai1, Naoki Kobayashi2, Yukiko Karuo1, Atsushi Tarui1, Kazuyuki Sato1, Masato Otuka1, Masaaki Omote1 (1. Fac. Pharm. Sci., Setsunan Univ., 2. Dep. Agric., Setsunan Univ.)

[29P-am111S]Evaluation of the Effect of Amino Acid Side Chain Ring Size in Amphipathic Peptides on Lipid Bilayers

○Akane Yoshikawa1, Takuma Kato1, Akiko Asano1, Mitsunobu Doi1 (1. Osaka Medical and Pharmaceutical University)

[29P-am112S]Evaluation of the influence on lipid bilayer membranes depending on the position of disubstituted amino acids in amphipathic helical peptides

○Hina Danno1, Takuma Kato1, Akiko Asano1, Mitsunobu Doi1 (1. Osaka Med. Pharm. Univ.)

[29P-am113]Development of zinc ion responsive photoremovable protecting groups

○Tomoya Hirano1, Daisuke Yasuda1, Yoshito Omachi1, Kentaro Sakamoto1, Ryota Tanaka1, Nomako Takano1, Hiroyuki Kagechika2 (1. Fac. Pharm., Osaka Med. Pharm. Univ., 2. Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ.)

[29P-am114]Development of photoactivatable / photoswitchable Raman probes and their application to super-resolution Raman imaging

○Minoru Kawatani1, Ayumi Komazawa2, Jingwen Shou3, Hiroyoshi Fujioka1, Yoshio Mita3,4, Yasuteru Urano2,5, Yasuyuki Ozeki3,6, Mako Kamiya1,7 (1. Dep. Life Sci. Tech., Tokyo Tech., 2. Grad. Sch. Pham. Sci., The Univ. of Tokyo, 3. Dep. Elect. Eng. Inform. Sys., The Univ. of Tokyo, 4. Nat. Cent. Sci. Res., The Univ. of Tokyo, 5. Grad. Sch. Med., The Univ. of Tokyo, 6. Res. Cent. Adv. Sci. Tech., The Univ. of Tokyo, 7. Int. Res. Front. Intit., Tokyo Tech)

[29P-am115S]A maturation inhibition assay system for SARS-CoV-2 3CL protease

○Yuki Yamauchi1, Sho Konno1, Noriko Omura1, Narumi Yoshioka1, Akihiro Taguchi1, Atsuhiko Taniguchi1, Yoshio Hayashi1,2 (1. Sch. Pharm., Tokyo Univ. Pharm. Life Sci., 2. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci.)

[29P-am116]Study on intramolecular base-assisted covalent bonding motifs.

○Hiroaki Ishida1, Yoshiki Igarashi1, Eri Abe1, Tatsuhiro Kyoya1, Toshimasa Itoh1 (1. Showa Pharmaceutical University)

[29P-am117S]Synthesis and PAL application of novel cinnamate-type diazirine with an azide group

○Keito Ogawa1, Azusa Sano1, Hiroki Tanimoto1, Takenori Tomohiro1 (1. Dep. Pharm. Sci., Univ. Toyama)

[29P-am118S]Development of an "organelle-specific iron chelator" for the regulation of intracellular iron kinetics.

○Yuna Yamada1, Yoshio Hayashi1,2, Yuta Fujikawa1 (1. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci., 2. Sch. Pharm., Tokyo Univ. Pharm. Life Sci.)

[29P-am119S]Design and synthesis of a fluorescent probe for durable imaging of endogenous esterase activity

○Momoka Sakamaki1, Yoshio Hayashi1,2, Yuuta Fujikawa1 (1. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci., 2. Sch. Pharm., Tokyo Univ. Pharm. Life Sci.)

[29P-am120S]Development of novel on/off-switchable photooxygenation-catalyst based on DASPI

○hideyuki okamoto1, Kaoru Ikekawa1, Shuko Amber Murano1, Jo Yamamoto1, Sho Konno1, Akihiro Taguchi1, Atsuhiko Taniguchi1, Yoshio Hayashi1,2 (1. Sch. of Pharm., Tokyo Univ. of Pharm. and Life Sci., 2. Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci.)

[29P-am121S]A Study on the Reactivity of Ethinylsulfonamide with Nucleophilic Amino Acids

○Tatsuhiro Kyoya1, Hiroaki Ishida1, Toshiaki Saitoh2, Toshimasa Itoh1 (1. Showa Pharm. Univ., 2. Nihon Pharm. Univ.)
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