The 144th Annual Meeting of the Pharmaceutical Society of Japan (Yokohama)
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Session Details

Poster Presentation(B) Pharmaceutical Physics

Structure, physical property, and reactivity of biological materials/Biopolymers/Biological membrane and artificial model membrane/Physical measurement /Membrane transport/Photochemistry, plasma chemistry

Sat. Mar 30, 2024 8:30 AM - 12:00 PM JST
Sat. Mar 30, 2024 11:30 PM - 3:00 AM UTC
[Poster 4] Exhibition Hall AB (1F)

[30P-am121S]Physiological role of newly found copper binding motif in cholecystokinin-8

○Yumi Nakayama1, Ryota Kawachi1, Nanami Kudo1, Moe Nohara1, Tomoaki Kumada1, Takashi Miura1 (1. Dept. Pharm. Sci., Int. Univ. Health and Welfare)

[30P-am122]The analysis of the seeding effects of D-isomerization of amino acids in amyloid β on fibril formation

○Takuya Murata1, Naoko Tate1 (1. Fac. Pharm. Sci., Teikyo Univ.)

[30P-am123S]Amyloidogenic peptide S192 from SARS-CoV-2 and its interaction with Aβ42

○Manami Yamaguchi1, Natsuko Goda1, Takeshi Tenno1,2, Emi Hibino1, Hidekazu Hiroaki1,2,3 (1. Grad. Sch. Pharm. Sci., Nagoya Univ., 2. BeCellBar, LLC, 3. COMIT)

[30P-am124]Slight structural changes and aggregation by asparagine deamidation in γS-crystallin

○koichi kato1,2, Tomoki Nakayoshi3,2, Eiji Kurimoto2, Akifumi Oda2,4, Yoshinobu Ishikawa1 (1. Facul. of Pharm. Sci., Shonan Univ. of Med. Sci., 2. Facul. of Pharm., Meijo Univ., 3. Grad. Inf. Sci., Hiroshima City Univ., 4. Inst. Prot. Res., Osaka Univ.)

[30P-am125S]Concentration quantification of ALS-causing proteins in phase-separated droplets using Raman imaging

○Mio Mizutome1, Kohei Yokosawa1, Shinya Tahara1, Shinji Kajimoto1,2, Nobuo Maita3, Masato Kato3, Takakazu Nakabayashi1 (1. Grad. Sch. Pharm. Sci., Tohoku Univ., 2. JST PRESTO, 3. QST)

[30P-am126]LLPS and liquid-solid phase transition of RNA-binding protein fused in sarcoma variant R495X : pressure-temperature phase diagram and pressure-jump experiments

○Yutaro Shiramasa1, Ryu Yamamoto1, Soichiro Kitazawa2, Ryo Kitahara1,2 (1. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 2. Col. Pharm., Ritsumeikan Univ.)

[30P-am127]LLPS and liquid-solid phase transition of RNA-binding protein fused in sarcoma variant R495X : fluorescence microscope observation

○Ryu Yamamoto1, Yutaro Shiramasa1, Soichiro Kitazawa2, Ryo Kitahara1,2 (1. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 2. Col. Pharm., Ritsumeikan Univ.)

[30P-am128S]Effects of small molecules on liquid-liquid phase separation of fused in sarcoma

○Fuka Sasaki1, Souichiro Kitazawa2, Ryo Kitahara1,2 (1. Grad. Sch. Pharm. Sci., Ritumeikan Univ., 2. Col. Pharm. Sci., Ritsumeikan Univ.)

[30P-am129]Urea suppresses and trimethylamine N-oxide enhances liquid-liquid phase separation of fused in sarcoma, a pathogenic protein of familial amyotrophic lateral sclerosis.

○Keiji Kitamura1, Fuka Sasaki1, Yutaro Shiramasa1, Ryo Kitahara1,2 (1. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 2. Col. Pharm., Ritsumeikan Univ.)

[30P-am130S]Effect of spatial arrangement of cation cluster structure on DNA aggregation morphology

○Io Tsuji1, Megumi Yabuta1, Momona Yamane1, Yuka Nakagawa2, Kenichi Yoshikawa3, Yuko Yoshikawa3 (1. Faculty of Pharm. Sci., DWCLA Univ., 2. Institute for Chemical Research, Kyoto Univ., 3. Faculty of Life and Medical Sci., Doshisha Univ.)

[30P-am131S]Protein aggregation induced by combination of thermal and agitation

○Zekun Wang1, Tetsuo Torisu1, Susumu Uchiyama1 (1. Grad. Sch. Eng., Osaka Univ.)

[30P-am132]The effects of replacement of Tyr171 with phenylalanine on photochemical properties in Halobacterium salinarum sensory rhodopsin II

○Jun Tamogami1, Risa Matsunami-Nakamura1, Miki Nishio1, Takashi Kikukawa2, Naoki Kamo1,2, Toshifumi Nara1 (1. College Pharm. Sci., Matsuyama Univ., 2. Fac. Adv. Life Sci., Hokkaido Univ.)

[30P-am133]An analysis of the secondary structure and thermal stability of Rab3A, a protein implicated in Parkinson's disease

○GENTA ITO1, TAISUKE TOMITA2, NAOKO TATE1 (1. Faculty Pharm. Sci., Teikyo Univ., 2. Grad. Sch. Pharm. Sci., Univ. Tokyo)

[30P-am134S]Effect of membrane lipid composition on aggregation and fibril formation of Parkinson’s disease-related α-synuclein

○Hiroki Kono1, Namba Norihiro1, Takashi Ohgita1, Nagao Kohjiro1, Saito Hiroyuki1 (1. Kyoto Pharm. Univ)

[30P-am135S]Design of novel heterorings by modifying the human 20S proteasome subunits and its application to protein integration

○Shiori Kajita1, Fuka Ikami1, Kana Kamiya1, Eri Kawasaki1, Shiori Kakiya1, Masaki Fuijita1, Akifumi Oda1,2, Eiji Kurimoto1 (1. Facl. Pharm. Meijo Univ., 2. Inst. Protein Res. Osaka Univ.)

[30P-am136S]Novel protein oligomer formation by applying domain swapping of human proteasome assembly chaperon PAC4

○Mizuki Tsubouchi1, Yota Suzuki1, Yuka Akiyama1, Akifumi Oda1,2, Eiji Kurimoto1 (1. Facl. Pharm. Meijo Univ., 2. Inst. Protein Res. Osaka Univ.)

[30P-am137S]In vitro reconstitution of human 20S proteasome alpha ring using mutated subunits

○Kiwako Minei1, Morihiro Kiriya1, Chikano Souda1, Akifumi Oda1,2, Eiji Kurimoto1 (1. Facl. Pharm. Meijo Univ., 2. Inst. Protein Res. Osaka Univ.)

[30P-am138]Relationship between instability in VL-VH interaction and molecular recognition in rheumatoid factor RF-TS1

Rina Takashima1, Enami Nishizaki1, Maruto Yamamoto1, Makiko Kikuchi2, Nobutaka Shimizu2, ○Mitsunori Shiroishi1 (1. Dept. of Biol. Sci. and Technol., Tokyo Univ. of Sci., 2. IMSS, KEK)

[30P-am139S]Effects of arginine counterions on IgG aggregation

○Kenshiro Ariki1, Masakazu Fukuda1, Toru Takarada1, Kanako Takahashi2, Shunsuke Saito2, Masafumi Tanaka1 (1. Kobe Pharm. Univ., 2. Synplogen Co., Ltd.)

[30P-am140S]Analyses of the interactions between liposomes and soluble colonization factor secreted from enterotoxigenic Escherichia coli

○Shinya Ichioka1, Minato Iimori1, Hiroya Oki2, Tomoya Imai3, Shigeaki Matsuda2, Tetsuya Iida2,4, Takuya Yoshida1, Tadayasu Ohkubo1,4, Shota Nakamura2,4, Kazuki Kawahara1,4 (1. Grad. Sch. Pharm. Sci., Osaka Univ., 2. RIMD, Osaka Univ., 3. RISH, Kyoto Univ., 4. CiDER, Osaka Univ.)

[30P-am141S]Evaluation of Ligand Binding Ability of GPCRs Sollubilized with Novel Phospholipid Derivatives

○Haruka Hoshi1, Kenichi Kawano1, Takahiro Fujiwara2, Yousuke Yamaoka1,3, Yusuke Kuroda1, Kiyosei Takasu1, Katsumi Matsuzaki1 (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. WPI-iCeMS, Kyoto Univ., 3. Fac. Pharm. Sci., Hyogo Med. Univ.)

[30P-am142S]Evaluation of phospholipid composition control mechanism focusing on the localization of biosynthetic enzymes

○Yurika Hiraoka1, Tomoka Miyata1, Kohjiro Nagao1, Hiroyuki Saito1 (1. Kyoto Pharm. Univ.)

[30P-am143]Correlation between cell membrane damage and photoinactivation on Candida by photosensitizers

○Hisato Kato1, Rio Toshimori1, Kazufumi Masuda1 (1. Sch. Pharm., Shujitsu Univ.)

[30P-am144]Effect of conformational constraints on apolipoprotein E-derived amphipathic peptide: insight into cell membrane penetration

○YUKI TAKECHI-HARAYA1, Takashi Ohgita2, Akiko Usui1, Kazuchika Nishitsuji3,4, Kenji Uchimura4, Yasuhiro Abe1, Ryuji Kawano5, Monika I Konaklieva6, Mart Reimund7, Alan T Remaley7, Yoji Sato1, Ken-ichi Izutsu8, Hiroyuki Saito2 (1. Division of Drugs, National Institute of Health Sciences, 2. Kyoto Pharmaceutical University, 3. Wakayama Medical University, 4. UMR 8576 CNRS, Université de Lille, 5. Tokyo University of Agriculture and Technology, 6. American University, 7. National Institutes of Health, 8. International University of Health and Welfare)

[30P-am145S]Effect of monounsaturated fatty acid-containing phospholipids on high-density lipoprotein formation by ABCA1

○Mayu Matsuo1, Norihiro Namba1, Kohjiro Nagao1, Hiroyuki Saito1 (1. Kyoto Pharm.Univ.)

[30P-am146S]Development of Lipid Scrambling Peptides with Different Phosphatidylserine Exposure Activities

○Sota Shibasaki1, Hiroyuki Nakao1, Keisuke Ikeda1, Minoru Nakano1 (1. Toyama Univ.)

[30P-am147S]Selective anticancer activities of low pH-responsive anticancer peptides and a peptide−anticancer drug conjugate

○Aoi Taniguchi1, Kenichi Kawano1, Katsumi Matsuzaki1 (1. Grad. Sch. Pharm. Sci., Kyoto Univ.)

[30P-am148]Investigation of lipid peroxidation by cold atmospheric pressure plasma irradiation.

○Tokuko Takajo1, Aya Yokozeki1, Kazunori Tsuchida1, Kazunori Anzai1 (1. Nihon Pharm. Univ.)

[30P-am149S]Regulation of phospholipid fatty acid composition by carbonic anhydrase

○Kana Matsumoto1, Kohjiro Nagao1, Hiroyuki Saito1 (1. Kyoto Pharm. Univ.)

[30P-am150S]Label-free evaluation of supersulfides in living cells using Raman microscopy

○Keisuke Koga1, Shinji Kajimoto1,2, Shinya Tahara1, Takakazu Nakabayashi1 (1. Grad. Sch. Pharm. Sci., Tohoku Univ., 2. JST PRESTO)

[30P-am151S]Development of a lipid radical probe applicable to click chemistry

○Sota Kawano1, Moe Tanaka2, Kota Saito2, Yuta Matsuoka3, Kazushi Morimoto2, Mirinthorn Jutanom2, Ken-ichi Yamada2 (1. Fac. Pharm. Sci., Kyushu-u Univ., 2. Grad. Sch. Pharm. Sci., Kyushu-u Univ., 3. Grad. Sch. Med. Kyoto Univ.)

[30P-am152S]Para-Substituent Effects on Reactivity Toward Ascorbate of 4-Oxo-TEMPO Derivatives Containing Phenyl Group at the C-2 Substituent

○Karin Nagahama1, Toshihide Yamasaki1, Kohei Sano1, Takahiro Mukai1 (1. Kobe Pharm. Univ.)

[30P-am153]Role of acidic amino acid residues in the pH-dependent conversion mechanism of substrate binding energy in the multidrug efflux transporter EmrE from Escherichia coli.

○Kazumi Shimono1, Shuichi Miyamoto1, Seiji Miyauchi2 (1. Fac. Pharm. Sci., Sojo University, 2. Fac. Pharm. Sci., Toho University)

[30P-am154S]Development of pH-sensitive fusogenic peptides for cytosolic delivery of therapeutic molecules

○Yuki Shibahara1, Ikuhiko Nakase2 (1. Sch. Sci., Coll. Life, Env. Adv. Sci., Osaka Prefecture Univ., 2. Grad. Sch. Sci., Osaka Metropolitan University.)

[30P-am155S]Exosomal membrane modification of arginine-richpeptides using curvature-recognition peptides forenhanced intracellular delivery

○Miho Nakabo1, Kenichi Kawano2, Daisuke Fujiwara1,3, Masataka Michigami1,3, Katsumi Matsuzaki2, Ikuo Fujii1,3, Ikuhiko Nakase1,3 (1. Sch. Sci., Coll. Life, Env. Adv. Sci., Osaka Prefecture Univ., 2. Grad. Sch. Pharm. Sci., Kyoto Univ., 3. Grad. Sch. Sci., Osaka Metropolitan University)

[30P-am156]Evaluation of an inkjet-based technology for cytosolic delivery of therapeutic molecules using cell-penetrating peptides

Mika Omura1, ○Sohei Ninomiya2, Yoshimasa Kawaguchi3, Daisuke Fujiwara1,2, Masataka Michigami1,2, Tomoka Takatani-Nakase4, Ikuo Fujii1,2, Shiroh Futaki3, Ikuhiko Nakase1,2 (1. Grad. Sch. Sci., Osaka Metropolitan University, 2. Coll. Life Env. Adv. Sci., Osaka Prefecture University, 3. Inst. Chem. Res., Kyoto Univ., 4. Dep. Pharm. Mukogawa Women's Univ.)

[30P-am157S]Degradation of organic dyes by TiO2 photocatalyst with metal nanoparticles and their electrochemical evaluation

○Taichi Yuri1, Yuto Takenaka1, Akira Kawashima1, Shigeru Kohtani1 (1. Hyogo Medical Univ.)

[30P-am158S]Investigation of surface condition of mesoporous silica-coated TiO2 for efficient adsorption and photocatalytic degradation of organic molecules

○Sayaka Ikeda1, Honoka Yuasa1, Yukiko Kajimoto1, Akira Kawashima1, Shigeru Kohtani1 (1. Hyogo Medical Univ.)

[30P-am159S]Improvement of Volatile Organic Compound Degradation Activity by Calcination of Mesoporous Silica-Coated Titanium Dioxide

○Tomoya Murata1, Rina Aoki1, Akira Kawashima1, Shigeru Kohtani1 (1. Hyogo Medical Univ.)

[30P-am160S]Relationship between Chiral Co-Adsorbents and Titanium Oxide Crystals in the Photocatalytic Hydrogenation of Aromatic Ketones

○Mikako Tatsuta1, Yuta Uchiyama1, Genki Negoro1, Akira Kawashima1, Hideto Miyabe1, Shigeru Kohtani1 (1. Hyogo Medical Univ.)

[30P-am161S]Photocatalytic Reduction of Cyclohexenone by Titanium Dioxide

○Yusuke Oka1, Akira Kawashima1, Shigeru Kohtani1 (1. Hyogo Medical Univ.)

[30P-am162S]Composite of different rare earth fluoride nanocrystals and their photocatalytic activity

○Akito Tonosaki1, Naoki Nogami1, Makoto Kitayama1, Akira Kawashima1, Shigeru Kohtani1 (1. Hyogo Medical Univ.)

[30P-am163S]Synthesis of rare-earth fluoride nanocomposites doped with luminescent species and enhancement of their luminescent properties.

○Reo Tokunaga1, Makoto Kitayama1, Akira Kawashima1, Shigeru Kohtani1 (1. Hyogo Medical Univ.)

[30P-am164]Photodegradation of environmental mutagens and photoscission of DNA by xanthene dyes as photosensitizers through LED-light irradiation

Hideki Miyagi1, Nobumitsu Ura1, Mami Maita1, Naoki Mitarai1, Masahiko Inoguchi1, Hisato Kato2, Kazufumi Masuda2, ○Junichi Odo1,2 (1. Fac. SCI., Okayama Uni. Sci., 2. Sch. Pharm., Shujitsu Univ.)

[30P-am165]Photoinduced cytotoxicity caused by photochromic diarylethene

Yuma Nakagawa1, Kimio Sumaru2, Kana Morishita2, Keita Kirito3, ○Satoshi Yokojima4, Yuki Sakamoto5, Shinichiro Nakamura6, Kingo Uchida7 (1. Mol. Eng. Inst., Shiga Univ. Med. Sci., 2. AIST, 3. Faculty of Med., Univ. of Yamanashi, 4. Sch. Pharm., Tokyo Univ. Pharm. & Life Sci., 5. RIKEN, 6. Kumamoto Univ., 7. Faculty of Sci. & Tech., Ryukoku Univ.)

[30P-am166]Preparation of colon-targeting drug delivered polymeric prodrug of Diclofenac synthesized by mechanochemical solid-state polymerization.

○Yukinori Yamauchi1, Naoki Doi2, Shin-ichi Kondo2, Yasushi Sasai3, Masayuki Kuzuya4 (1. Department of Pharmaceutical Physical Chemistry, College of Pharmaceutical Sciences, Matsuyama University, 2. Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, 3. Gifu University of Medical Science, 4. Department of Health & Welfare, Chubu Gakuin University)

[30P-am167]Development of aggregation-induced emission organic molecules for application in photodynamic therapy

○Masayori Hagimori1, Tatsusada Yoshida2, Fumiko Hara1, Shinya Takada1, Yukiko Ogawa2, Keitaro Tanaka3 (1. Sch. Pharm., Mukogawa Women’s Univ., 2. Fac. Pharm. Sci., Nagasaki Int. Univ., 3. Shimonoseki Med. Ctr)

[30P-am168]Discovery of novel DPP8 inhibitors by fragment-based approach

○Shin-ichiro Ozawa1, Momoka Yada1, Ruri Sasaki1, Nobutada Tanaka1 (1. Sch. Pharm., Kitasato Univ.)

[30P-am169S]Improvement of the method for 3D image creation of crude drug specimens by photogrammetry

○Ryo Morishima1, Isamu Aizawa1, Tadahiro Yahagi1, Tomoko Takamiya1, Keichi Matsuzaki1, Koji Kobayashi1 (1. NIHON Univ.)

[30P-am170S]Introduction of the comparison scale in 3D image of crude drug specimens by photogrammetry

○Isamu Aizawa1, Ryou Morishima1, Tadahiro Yahagi1, Tomoko Takamiya1, Keiichi Matsuzaki1, Koji Kobayashi1 (1. School of Pharmacy, Nihon university)

[30P-am171]Signaling mechanisms regulating actin dynamics in mast cell activation

○Ruriko Suzuki1, Yoshikazu Inoh2, Satoru Yokawa2, Tadahide Furuno2, Naohide Hirashima1 (1. Grad. Sch. Pharm. Sci., Nagoya City Univ., 2. Sch. Pharm., Aichi Gakuin Univ.)

[30P-am172]A formulation using an insulin prodrug for avoiding hypoglycemia

○Satoshi Kitaoka1, Ryusei Ando1, Kaede Kobayashi1, Mako Okabe1, Chisato Mori1, Miho Koita1, Minori Kojima1, Hiroki Koyama1, Yuya Egawa1 (1. Faculty of Pharmacy and Pharmaceutical Sciences, Josai University)

[30P-am173]Investigation of a potentiation mechanism of a spin probe, TEMPOL, on the cytotoxicity of vitamin K3

○Shoko Okazaki1, Kanako Kobayashi1, Risako Tashiro1, Mai Kaieda1, Maiko Noshita1, Yuhei Ohta1, Keizo Takeshita1 (1. Fac. of Pharm. Sci., Sojo Univ.)

[30P-am174]Development of novel DNA methyltransferase assay using FRET

○Misato Ikeshita1, Seitaro Kamiya1, Tsutomu Kabashima1 (1. Nagasaki International Univ.)

[30P-am175]Preparation of Ketoprofen-Containing Nanoparticle Formulations Using a Combination of Roll Mill and Ultrasonic Homogenizer

○Momo Itokazu1, Tsutomu Kabashima1, Haruka Ide1, Seitaro Kamiya1 (1. Nagasaki international Univ.)
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