Presentation Information
[O-2-02]LEVELS OF NEUROACTIVE STEROID HORMONES IN ALCOHOL DEPENDENT PATIENTS OF DIFFERENT ETHNIC ORIGIN
Tamara V. Shushpanova, Nikolay A. Bokhan, Anna I. Mandel, *Svetlana V. Vladimirova (Mental Health Research Institute (Russia))
Keywords:
Cultural psychiatry,Galodif,new drug
Introduction: Disturbance of homeostasis of neuroactive steroids (NS) is a risk factor for development of mental and drug disorders. Development of new drugs that affect NS metabolism taking into account individual characteristics and ethnicity that form high risks of development of alcohol dependence (AD) is one of the therapeutic strategies. Objective: To study the levels of NS: cortisol (CS), progesterone (PG), testosterone (T) in Russian and Tuvan patients with AD under the influence of therapy with the original anticonvulsant Galodif (metachlorobenzhydryl urea). Material and methods: The study included: 23 healthy male volunteers, 38 Russian male patients with a diagnosis according to ICD 10 - F.10.232 and F.10.303, who were treated at the Mental Health Research Institute, Tomsk National Research Medical Center, RASci; 67 male patients of Tuvan nationality, treated at the Republican Narcological Dispensary (Kyzyl). The levels of steroid hormones CS, PG and T were determined using ELISA kits. Results: Comparative analysis of NS levels in patients with AD and healthy volunteers showed that the level of PG and T in the blood serum was significantly lower in patients. More pronounced changes were found in Tuvan patients. Reduced PG level leads to a decrease in endogenous modulators of GABA receptors in the CNS. The use of galodif (300 mg/day, 21 days) in patients caused a decrease in the symptoms of alcohol withdrawal syndrome and an increase in the level of PG and T, approaching the control value. The CS level was significantly higher in patients of Russian nationality, but more pronounced changes were noted in Tuvan patients.After therapy with galodif, the level of CS decreased. Conclusion: Changes in the level of NS in the blood of patients with AD reflect a violation of the regulation of NS hormones as one of the mechanisms of development.