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[P-29-02]Interpretation Bias and Irritability Mediate the Association between Cognitive Rigidity and Depression among Psychiatric Patients

*Eunkyung Kim1,3, Daeho Kim2, Joonho Choi2, Seon-cheol Park2, Jin-woong Yoon1 (1.Department of Psychiatry, Hanyang University Guri Hospital, Republic of Korea(Korea), 2.Department of Psychiatry, Hanyang University College of Medicine(Korea), 3.Department of Premedicine, Hanyang University College of Medicine(Korea))
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Keywords:

Cognitive rigidity,Interpretation Bias,Irritability,Depression

Introduction: Cognitive rigidity, characterized by persistent inflexible thinking and difficulty adapting to new information, has been linked to the onset and maintenance of depression. This study investigated roles of interpretation bias and irritability in the relationship between cognitive rigidity and depression among psychiatric patients.
Method: Data were collected from 74 psychiatric patients using the Cognitive Flexibility Inventory (CFI), Beck Depression Inventory-II (BDI-II), Ambiguous/Unambiguous Situations Diary Extended Version ( AUSD-EX), and the Brief Irritability Test (BITe). Regression analyses and bootstrapping methods were used to analyze the data.
Results: Cognitive flexibility negatively predicted depression. Moreover, interpretation bias significantly mediated the relationship between cognitive flexibility and depression, whereas irritability did not. However, interpretation bias and irritability sequentially mediated the effect of cognitive flexibility on depression.
Conclusion: The findings suggest that negative interpretation bias and irritability may play a significant role in the pathway linking cognitive rigidity and depression. Therefore, interventions aiming to reduce depressive symptoms should focus not only on enhancing cognitive flexibility but also on modifying negative interpretation bias toward ambiguous situations and managing irritability.