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[SY-102-02]The Possibility of Personalized Treatment for Major Depressive Disorder in the Re-work Program

*Hikaru Hori (Department of Psychiatry, Faculty of Medicine, Fukuoka University(Japan))
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Keywords:

Major depressive disorder,Re-work,cognitive function,social cognition

The number of workers in Japan on sick leave due to mental health-related illnesses is increasing. Even after returning to work after undergoing psychiatric treatment (pharmacotherapy, psychotherapy, environmental adjustment), it is known that the rate of return to sick leave is high1). We reported that the factors necessary for continued employment were activity, cognitive function, social adaptability, and benzodiazepine use2), 3), 4). We also reported on the effectiveness of the re-work program5). However, major depressive disorder is highly heterogeneous. Therefore, the rehabilitation required for each patient in the re-work program may differ. We examined the effectiveness of individualized rehabilitation for patients with major depressive disorder6). In this study, participants were randomly assigned to either the personalized treatment group or the usual treatment group, and underwent 8 weeks of rehabilitation treatment. Both groups showed improvements in neurocognitive function, social cognitive function, and emotional processing7). The social cognitive function of the personalized treatment group improved significantly. In the future, personalized rework programs tailored to the patient's situation may be required.
1) Hori H et al., 2013
2) Morita G, et al., J Occup Environ Med 5882: e56-57, 2016
3) Hori H et al., BMJ Open 11;9(9): e029705, 2019
4) Atake K et al., Psychiatry Res; 291: 113209, 2020
5) Tamasaki Y et al., 2017
6) Knight MJ, Baune BT. Front psychiatry 12:8:280, 2017
7) Knight MJ et al., Psychiatry Res 300:113906, 2021
8) Hawighorst A, Hori H et al., Psychiatry Res 330:115590, 2023