Presentation Information
[SY-112-04]Neurocognitive and behavioral profiles of children with tic disorders/Tourette syndrome with normal cognitive abilities
*Jin-Hwa Moon1, Minjung Park2, Min Sook Koh3 (1.Division of Pediatric Neurology, Department of Pediatrics, Hanyang university college of medicine (Korea), 2.Department of Pediatrics, Korea University Anam Hospital(Korea), 3.Department of Pediatrics, Hanyang University Guri Hospital(Korea))
Keywords:
Tic disorder,Tourrete syndrome,Neurocognitive profile,Behavior problem,children
The incidence of tic disorders has been increasing in Korea. Children with tic disorders or Tourrete syndrome (TDTS) who visiting pediatric neurologists appeared to have increased during COVID-19 pandemic. Tic disorders are often accompanied by various behavioral problems and can be the comorbidities of other neurodevelopmental disorders or psychiatric conditions. However, it may not be appropriate to directly apply the data obtained from patients with various developmental problems to patients visiting the hospital for the first time. In order to understand the effects of tic brain itself, we investigated the behavioral and cognitive characteristics of children with tic disorders with normal cognitive function and compared them with healthy controls. The results of neurocognitive and behavioral assessments were analyzed for 36 children with TDTS (male:female=27:9), aged 6 to 14 years (mean age±SD: 9.5±2.1 years). The results of Korean-Wechsler intelligence scale for children (K-WISC version-III, IV, V) showed that across-averaged mean full scale IQ was 98.8±11.7. In TDTS group, visuo-spatial cognitive abilities tended to be lower than verbal comprehension. In the results of Korean-child behavior checklists (K-CBCL) for the emotional and behavioral problems, the TDTS group showed significantly higher proportions of borderline or clinical ranges in almost all problems; internalizing, externalizing, and total problems, anxious/depressed, somatic complaints, thought, anxiety and somatic problems. Attention-deficit/hyperactivity(ADHD), obsessive-compulsive and stress problems were higher in TDTS group. The mean Korean-ADHD Rating Scale-IV score was 11.3±7.7 and 17.1% was above the clinical cutoff (more than 19 by parent) for ADHD. Our results showed that children with TDTS with normal cognitive level exhibited diverse behavioral problems at the first visit. Behavioral assessments should be incorporated as initial evaluations for TDTS even in patients with tic only symptoms. (The content of this abstracts is being prepared for publication in Annals of Child Neurology)