Presentation Information
[SY-56]Current status of psychiatric research using genetic medicine and genomic medicine
Importance of collaborative research among East Asians
Nakao Iwata1, Weihua Yue2, Po-Hsiu Kuo3, Hailiang Huang4 (1.Fujita Health University School of Medicine(Japan), 2.Peking University Sixth Hospital(China), 3.National Taiwan University(Taiwan), 4.the Broad Institute of MIT and Harvard(United States of America))
Keywords:
genetics and epidemiology,pharmaogenetics,schizophtenia,bipolar disorder
Despite various efforts to elucidate the biological pathogenesis of major mental disorders, much remains unclear at present. No clear biomarkers have been identified, and since the disease entity is the brain, which is extremely difficult to access in vivo, current medical science approaches cannot easily elucidate the pathogenesis.
Genetic factors in major mental disorders such as schizophrenia and bipolar disorder have been observed for a long time. If Mendel's laws are true, clues to the pathogenesis of mental disorders are certainly recorded in genetic information.
Recent advances in genomic medicine research, particularly the development and low-cost availability of whole-genome sequencing technology and the advancement of computer technology enabling rapid analysis of large amounts of data, have yielded significant results in genomic medicine research.
In schizophrenia and bipolar disorder, hundreds of associated gene loci and genes have been identified. By combining various analytical techniques with image and multiomics analysis data, findings that shed light on the pathogenesis of these disorders based on genomic information are gradually accumulating.
In this symposium, we will introduce and discuss the latest findings in genetic epidemiology, genomic medicine, and pharmacogenetics aimed at elucidating the pathophysiology of mental disorders, based on collaborative research across Japan, China, Taiwan, and various other ethnic groups around the world.
Genetic factors in major mental disorders such as schizophrenia and bipolar disorder have been observed for a long time. If Mendel's laws are true, clues to the pathogenesis of mental disorders are certainly recorded in genetic information.
Recent advances in genomic medicine research, particularly the development and low-cost availability of whole-genome sequencing technology and the advancement of computer technology enabling rapid analysis of large amounts of data, have yielded significant results in genomic medicine research.
In schizophrenia and bipolar disorder, hundreds of associated gene loci and genes have been identified. By combining various analytical techniques with image and multiomics analysis data, findings that shed light on the pathogenesis of these disorders based on genomic information are gradually accumulating.
In this symposium, we will introduce and discuss the latest findings in genetic epidemiology, genomic medicine, and pharmacogenetics aimed at elucidating the pathophysiology of mental disorders, based on collaborative research across Japan, China, Taiwan, and various other ethnic groups around the world.