Presentation Information
[P2-68]Green Synthesized Cobalt Ferrite: on Cancer Tumor Hyperthermia and Targeting Therapy
*An-Cheng Aidan Sun1,2,3, Chien-Shiun Liao1, Sea-Fue Wang4, Glemarie C. Hermosa1, Yu-Xiu Deng1 (1. Department of Chemical Engineering & Materials Science, Yuan Ze University (Taiwan), 2. Ming-Kuan Biomedical Technology Corporation (Taiwan), 3. Graduate School of Biotechnology and Bioengineering, Yuan Ze University (Taiwan), 4. Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taiwan))
Keywords:
cobalt ferrite,green synthesis,high-frequency,hyperthermia,drug delivery
In recent years, the cancer mortality rate in the country has remained persistently high, consistently ranking as the leading cause of death for several years. Both domestically and internationally, there has been a vigorous development of cancer treatment medications and related medical equipment with the aim of reducing mortality and extending lifespans. The main cancer treatment modalities in recent years include radiation therapy, chemotherapy, and surgical excision. Hyperthermia treatment has also shown promising potential, as it can enhance the success rates of chemotherapy and radiation therapy. Combining hyperthermia treatment with magnetic nanoparticles has demonstrated efficacy in experiments involving mice, with the hope of achieving similar success in human subjects. Therefore, our objective is to identify magnetic nanoparticles that can safely and effectively induce controlled hyperthermia.The core purpose of this research is to employ a green hydrothermal synthesis method using a solution derived from the Echeveria plant, creating magnetic nanoparticles of cobalt ferrite (CoFe2O4). These nanoparticles possess low biotoxicity, superparamagnetic, and biocompatibility. The study aims to investigate the heating efficiency under hyperthermia conditions and drug release effects of these magnetic nanoparticles, with the ultimate goal of evaluating their potential for targeted cancer cell therapy.We conducted analyses of crystal structure, magnetic properties, and microstructure of the samples using XRD, VSM, SEM, and TEM. High-frequency testing was employed to assess the magnetic nanoparticles' induction heating capability in alternating current fields. Results indicated that the cobalt ferrite nanoparticles exhibit a spinel oxide structure, displaying superparamagnetic properties with a saturation magnetization of approximately 55 emu/g. Microstructural analysis revealed a spherical distribution of cobalt ferrite particles, with an average size of around 8-12 nm. Significantly, these cobalt ferrite nanoparticles demonstrated substantial heating effects in alternating current fields, substantiating their potential application in magnetic hyperthermia for cancer treatment. In subsequent phases, we intend to modify the functional groups of the nanoparticles through polymer coating and attach cancer drugs to explore the feasibility of drug release.