Presentation Information
[O9-06]Mouse Strain Differences in Time Estimation are Related to Impulsive Behavior
*MARIELENA EUDAVE-PATIÑO1, JONATHAN BURITICÁ2, JAIME EMMANUEL ALCALÁ TEMORES 2 (1. UNIVERSIDAD AUTÓNOMA DE AGUASCALIENTES (Mexico), 2. UNIVERSIDAD DE GUADALAJARA (Mexico))
Keywords:
temporal estimation,strain differences,impulsive behavior,mice
Differences between mouse strains have significantly impacted the results of various studies; however, the underlying sources of these differences remain unclear. Differences among mouse strains have been observed in locomotor activity, lever and nosepoke responses, impulsivity, and temporal estimation. Some studies suggest that these differences may be linked to genetics of the strains, although further research is needed to clarify these findings. The objective of this experiment was to test CD1 and C57BL/6 strains using a peak procedure, a progressive ratio schedule, a modified peak procedure, and a differential reinforcement of low rate (DRL) schedule. These procedures were used to determine whether there were differences in time estimation and the factors influencing performance on such schedules. The analysis of the curvature index in fixed interval (FI), peak, and modified peak procedures revealed that CD1 mice exhibited a higher curvature index compared to C57BL/6 mice. Additionally, differences in performance were observed in the analysis of peak trials within the peak and modified peak procedures, with CD1 mice showing a higher response rate at the start of the trial compared to C57BL/6 mice. In the progressive ratio, the post-reinforcement pause was longer in the C57BL/6 strain than in CD1 mice, but no significant differences were found in breakpoint levels between the two strains. In DRL procedure, C57BL/6 mice displayed higher inter-response times (IRTs) compared to CD1 mice, and the distribution of IRTs differed according to strain. These results indicate that there are strain-related differences in postprandial behavior that may be associated with impulsivity. Specifically, CD1 mice appear to exhibit greater impulsivity compared to C57BL/6 mice, as evidenced by their behavioral patterns in the tasks analyzed