Presentation Information
[P1-09]Temporal Expectation and Dopamine: Insights from Omission Oddball Paradigm in Rats
*Riko Iizuka1, Ryotaro Yamaki 1, Tomoyo Shiramatsu-Isoguchi1, Shota Morikawa 2, Yuji Ikegaya 3, Hirokazu Takahashi 1 (1. Graduate School of Information Science and Technology, The University of Tokyo (Japan), 2. Graduate School of Science and Faculty of Science, University of Tokyo (Japan), 3. Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, The University of Tokyo (Japan))
Keywords:
Dopamine,Oddball,In Vivo
Dopamine plays a crucial role in perceiving time, with evidence suggesting that increases or decreases in dopamine levels can speed up or slow down the internal clock. Alongside its apparent influence on time perception, dopamine encodes reward, punishment, and motivation. This multifaceted nature makes it challenging to fully understand how dopamine affects time perception in different contexts. Furthermore, dopamine responds to neutral stimuli, such as white noise, that do not have positive or negative valence. Given that many time perception studies used neutral stimuli to investigate how each sensory modality perceives time, it is important to examine dopamine's response to these stimuli for accurate interpretation of previous research.
We focused on the effects of auditory stimuli's temporal expectations on dopamine. White noise was presented to rats, and dopamine was measured in vivo with high temporal resolution using fibre photometry. The omission oddball paradigm was used to manipulate temporal expectation. It has been suggested that neural activity during omission reflects a prediction error, as the standard stimuli create a temporal expectation for stimulus input.
Our results showed that dopamine increased phasically immediately after the sound onset, followed by a decrease, forming a wave pattern without repetition-induced suppression. When stimuli were omitted at unexpected timings, dopamine showed a gradual tendency to increase. Notably, with the typical oddball paradigm of standard and deviant defined by the frequency of stimuli, the amplitude of dopamine response was more significant in deviant stimuli. This phenomenon supports the theory that dopamine influences time perception and aligns with the previous reports of duration dilation for unpredictable stimuli. Furthermore, the fact that dopamine is affected by manipulating temporal expectancies, even for non-rewarding sensory stimuli, supports the view that time perception and dopamine are tightly involved.
We focused on the effects of auditory stimuli's temporal expectations on dopamine. White noise was presented to rats, and dopamine was measured in vivo with high temporal resolution using fibre photometry. The omission oddball paradigm was used to manipulate temporal expectation. It has been suggested that neural activity during omission reflects a prediction error, as the standard stimuli create a temporal expectation for stimulus input.
Our results showed that dopamine increased phasically immediately after the sound onset, followed by a decrease, forming a wave pattern without repetition-induced suppression. When stimuli were omitted at unexpected timings, dopamine showed a gradual tendency to increase. Notably, with the typical oddball paradigm of standard and deviant defined by the frequency of stimuli, the amplitude of dopamine response was more significant in deviant stimuli. This phenomenon supports the theory that dopamine influences time perception and aligns with the previous reports of duration dilation for unpredictable stimuli. Furthermore, the fact that dopamine is affected by manipulating temporal expectancies, even for non-rewarding sensory stimuli, supports the view that time perception and dopamine are tightly involved.