Presentation Information
[P2-07]Time in the primate hippocampus during a metronome task
*Mildred Salgado-Menez1, Ana Maria Malagon1, Victor de Lafuente1 (1. Universidad Nacional Autonoma de Mexico (Mexico))
Keywords:
hippocampus,visual task,interval timing,neural dynamics
We addressed how interval time is encoded in the non-human primate hippocampus. Are time-encoding hippocampal signals susceptible to contextual changes? And if they are, how are these signals dynamically adapted? (visual vs. non-visual). At the single cell level, we describe mixed selectivity to different task features, followed by a population analysis using PCA, where we report the geometry of abstract information representation in the hippocampus that accurately reflected the diverse tuning properties of individual cells that differed between visual and non-visual epochs of the task. We observed oscillatory activity at individual and population levels at the non-visual epoch of the timing task. The fact that some drift of the temporal and spatial information was being represented without any relevant visual input proves that this short-term memory function operates without the regular input that provides the reference position for a spatial view. These findings are evidence for the operation of an attractor that influences the activity of hippocampal pyramidal cells.