[P3] Poster: Day 3

[P3-14] Impact of Retrosplenial Cortex Resection on Temporal Estimation in CD1 Mice

*Tania Campos-Ordoñez¹, Marielena Eudave-Patiño^2,3, Emmanuel Alcalá², Jonathan Buriticá² (1. Departamento de Biología Celular y Molecular, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara (Mexico), 2. Centro de Estudios e Investigaciones en Comportamiento, Universidad de Guadalajara (Mexico), 3. Universidad Autónoma de Aguascalientes (Mexico))

Keywords:

Retrosplenial cortex,Temporal Estimation,Peak procedure,CD1 mouse

The retrosplenial cortex (RSC), located in the posterior region of the brain, exhibits intricate connections to sensory and cognitive areas and is correlated with memory impairments. The RSC plays a crucial role in forming associative memory, long-term object recognition, navigation, and contextual memory. Recent evidence highlights its involvement in temporal coding, suggesting its participation in episodic memory and tracking temporal intervals during cognitive tasks. Similar to hippocampal time cells, several RSC neurons exhibit activity at specific intervals during delay periods, yet their role in temporal estimation remains unclear. This study employed an experimental model involving anterior RSC resection in adult CD1 mice, utilizing sham-operated animals as controls. Mobility was assessed in an open field, while temporal estimation was measured using a peak procedure. Results indicated that RSC resection did not impair mobility in male or female mice. However, male mice exhibited reduced response rates during the temporal estimation task compared to females, without significant differences in accuracy, precision, or attention across peak, gap, and distractor trials. The diminished response rate in males potentially reflects reduced motivation. Traditionally, the RSC is associated with spatial cognition, memory, and contextual processing. However, its connections to limbic structures might also play a role in motivation, especially in tasks that demand sustained engagement or associative learning.