Presentation Information
[F2-140]Michael acceptor-containing programmed synthetic alkaloid covalently binds host POLE3 and inhibits HBV replication
*Misao Himeno1,2, Nobuto Kaneko3, Yuhi Kobayashi3, Ryo Tanifuji3, Hiroki Kubota4, Haruki Mizoguchi5, Makoto Muroi6, Takehiro Suzuki6, Masaya Sugiyama7, Naoshi Dohmae6, Hiroyuki Osada6, Taketomo Kido2, Atsushi Miyajima2, Hiroki Oguri3 (1. Department of Developmental Medical Sciences, The University of Tokyo (Japan), 2. Laboratory of Cell Growth and Differentiation, Institute for Quantitative Biosciences, The University of Tokyo (Japan), 3. Department of Chemistry, Graduate School of Science, The University of Tokyo (Japan), 4. Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology (Japan), 5. Graduate School of Natural Science and Technology, Okayama University (Japan), 6. Centre for Sustainable Resource Science, RIKEN (Japan), 7. Department of Viral Pathogenesis and Control, National Institute of Global Health and Medicine (Japan))

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