講演情報

11:10 〜 11:30

[3B-2-03]Enhancing PROTAC Membrane Permeability by Combining Amide-to-Ester Substitution and Linker Methylation Strategies

*Mazin Abdelwahid¹, Eisuke Hayakawa¹, Keigo Hirai¹, Mayumi Ishii², Kayoko Kanamitsu², Saori Yasuda¹, Fumiaki Ohtake^3,4, Shinichi Sato^1,5, Shusuke Tomoshige¹, Minoru Ishikawa¹ (1. Graduate School of Life Sciences, Tohoku University, 2. Drug Discovery Initiative, The University of Tokyo, 3. School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4. Institute for Advanced Life Sciences, Hoshi University, 5. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University)

キーワード：

PROTACs、Membrane permeability、Chameleonicity、Linker optimization、Beyond Rule of 5 (bRo5)、Medicinal chemistry

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